CD4+ T cells, also known as T‐helper (Th) cells, play an important role in orchestrating
adaptive immune responses to various infectious agents. They are also involved in the …

CD4 T cells play critical roles in mediating adaptive immunity to a variety of pathogens. They
are also involved in autoimmunity, asthma, and allergic responses as well as in tumor …

Naïve CD4 T cells, on activation, differentiate into distinct T helper (Th) subsets that produce
lineage-specific cytokines. By producing unique sets of cytokines, effector Th subsets play …

CD4+ T cells are crucial in achieving a regulated effective immune response to pathogens.
Naive CD4+ T cells are activated after interaction with antigen‐MHC complex and …

CD4+ T helper (Th) cells are critical in homeostasis and host defense but are also central to
the development of various autoimmune diseases if they become dysregulated. Specifically …

In the periphery, upon antigen recognition by αβTCR, naïve CD4 T cells undergo functional
differentiation and acquire the ability to produce a specific set of cytokines. At least four Th …

CD4+ T helper cells are key regulators of host health and disease. In the original model,
specialized subsets of T helper cells are generated following activation through lineage …

T‐helper (Th) cells play critical roles within the mammalian immune system, and the
differentiation of naive CD 4+ T cells into distinct T‐helper subsets is critical for normal …

The discovery of CD4+ T cell subset–defining master transcription factors and framing of the
Th1/Th2 paradigm ignited the CD4+ T cell field. Advances in in vivo experimental systems …

Combined with TCR stimuli, extracellular cytokine signals initiate the differentiation of naive
CD 4+ T cells into specialized effector T‐helper (Th) and regulatory T (Treg) cell subsets …