Synthesis of amphiphilic Janus dendrimer and its application in improvement of hydrophobic drugs solubility in aqueous media

F Najafi, M Salami-Kalajahi… - European Polymer …, 2020 - Elsevier
Classic dendrimers are not used in many specific applications such as simultaneous loading
of different drugs due to the existence of identical end groups. The possibility of designing …

Synthesis of novel dendrimers having aspartate grafts and their ability to enhance the aqueous solubility of model drugs

L Ouyang, L Ma, B Jiang, Y Li, D He, L Guo - European journal of medicinal …, 2010 - Elsevier
In this study, a series of aspartate based dendrimers with different cores were synthesized in
a convergent approach and well characterized by NMR and MS techniques. The aqueous …

A comparative study on solubility improvement of tetracycline and dexamethasone by poly (propylene imine) and polyamidoamine dendrimers: An insight into …

F Najafi, M Salami‐Kalajahi… - … Research Part A, 2020 - Wiley Online Library
Many of new chemical discovered in pharmaceutical industry are hydrophobic compounds.
Various techniques have been used to overcome solubility problems of hydrophobic drugs …

Janus-type dendrimers: Synthesis, properties, and applications

F Najafi, M Salami-Kalajahi… - Journal of Molecular …, 2022 - Elsevier
Dendrimers are among the most popular multifaceted systems. Conventional dendrimers
cannot be used in many specific applications such as simultaneous loading of different …

[PDF][PDF] Polypropylene imine dendrimer mediated solubility enhancement: effect of pH and functional groups of hydrophobes

U Gupta, HB Agashe, NK Jain - J Pharm Pharm Sci, 2007 - academia.edu
Dendrimers today are known for their three dimensional, monodispersed, highly branched,
macromolecular nano-scopic architecture with number of reactive end groups. Dendrimers …

One platform comparison of solubilization potential of dendrimer with some solubilizing agents

S Jain, P Kesharwani, RK Tekade… - Drug development and …, 2015 - Taylor & Francis
Objective: To compare various solubilizing agents for their solubilizing propensity as well as
effect of pH, concentration and time on solubility of a highly hydrophobic drug. Materials and …

An emerging class of amphiphilic dendrimers for pharmaceutical and biomedical applications: Janus amphiphilic dendrimers

DR Sikwal, RS Kalhapure, T Govender - European Journal of …, 2017 - Elsevier
In recent years, a new class of dendrimer, known as Janus dendrimers (JDs), has attracted
much attention due to their different structures and properties to the conventional symmetric …

Dendrimers: novel polymeric nanoarchitectures for solubility enhancement

U Gupta, HB Agashe, A Asthana, NK Jain - Biomacromolecules, 2006 - ACS Publications
Poor solubility and hydrophobicity of drugs/bioactives limit their possible applications in drug
delivery and formulation development. Apart from conventional methods of solubility …

Dendrimer for solubility enhancement

B Gorain, M Pandey, H Choudhury, GK Jain… - Dendrimer-based …, 2021 - Elsevier
A drug is effective in their molecular form; thus solubility in the biological fluid is important.
Pharmaceutical researchers are continuously working on the improvement of solubility of …

Evaluation of poly (amidoamine) dendrimers as potential carriers of iminodiacetic derivatives using solubility studies and 2D-NOESY NMR spectroscopy

M Markowicz, P Szymański, M Ciszewski, A Kłys… - Journal of biological …, 2012 - Springer
The interactions between dendrimers and different types of drugs are nowadays one of the
most actively investigated areas of the pharmaceutical sciences. The interactions between …