Endogenous cytoplasmic DNA (cytoDNA) species are emerging as key mediators of
inflammation in diverse physiological and pathological contexts. Although the role of …

Systemic inflammation is central to aging‐related conditions. However, the intrinsic factors
that induce inflammation are not well understood. We previously identified a cell …

Plasma cell‐free DNA (cf‐DNA) has recently emerged as a potential biomarker of aging,
reflecting systemic inflammation, and cell death. In addition, it has been suggested that cf …

How DNA damage leads to chronic inflammation and tissue degeneration with aging
remains to be fully resolved. Here, we show that DNA damage leads to cellular senescence …

To lessen the “wear and tear” of existence, cells have evolved mechanisms that
continuously sense DNA lesions, repair DNA damage and restore the compromised …

Adult stem cells ensure tissue homeostasis and regeneration after injury. Due to their
longevity and functional requirements, throughout their life stem cells are subject to a …

Besides constituting a first layer of defense against microbial challenges, the detection of
cytosolic DNA is fundamental for mammalian organisms to control malignant transformation …

Chronic inflammation, increased reactivity to self-antigens and incidences of cancer are
hallmarks of aging. However, the underlying mechanisms are not well understood. Age …

Endogenous DNA is primarily found intracellularly in nuclei and mitochondria. However,
extracellular, cell-free (cf) DNA, has been observed in several pathological conditions …

To counteract DNA damage, cells employ genome maintenance pathways that are directed
inward, relentlessly to scan and repair the genome. Adaptive and innate immune …