Association of Hepatitis C Virus—Specific CD8+ T Cells with Viral Clearance in Acute Hepatitis C

NH Grüner, TJ Gerlach, MC Jung… - The Journal of …, 2000 - academic.oup.com
CD8+ T lymphocytes play a major role in antiviral immune defense. Their significance for
acute hepatitis C is unclear. Our aim was to correlate the CD8+ T cell response with the …

CD8+ T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained

F Lechner, NH Gruener, S Urbani… - European journal of …, 2000 - Wiley Online Library
Cellular immune responses are likely to play a key role in determining the clinical outcome
in acute infection with hepatitis C virus (HCV), but the dynamics of such responses and their …

T-lymphocyte response to hepatitis C virus in different clinical courses of infection

P Botarelli, MR Brunetto, MA Minutello, P Calvo… - Gastroenterology, 1993 - Elsevier
Background: To assess the role played by the immune response in the outcome of hepatitis
C virus infection, the CD4+ T-lymphocyte response to viral antigens was studied in infected …

Differential CD4+ and CD8+ T-cell responsiveness in hepatitis C virus infection

KM Chang, R Thimme, JJ Melpolder, D Oldach… - Hepatology, 2001 - Elsevier
This study was performed to compare the vigor and phenotype of virus-specific CD4+ and
CD8+ T-cell responses in patients with different virologic and clinical outcomes after …

[HTML][HTML] CD4+ T cell responses in hepatitis C virus infection

N Semmo, P Klenerman - World journal of gastroenterology: WJG, 2007 - ncbi.nlm.nih.gov
Hepatitis C virus (HCV) infection is a major cause of liver damage, with virus-induced end-
stage disease such as liver cirrhosis and hepatocellular carcinoma resulting in a high rate of …

Recurrence of hepatitis C virus after loss of virus-specific CD4+ T-cell response in acute hepatitis C

JT Gerlach, HM Diepolder, MC Jung, NH Gruener… - Gastroenterology, 1999 - Elsevier
Background & Aims: The prospective comparison of patients with acute hepatitis C virus
(HCV) who spontaneously clear the virus with those who cannot achieve viral elimination …

Detection of functionally altered hepatitis C virus-specific CD4+ T cells in acute and chronic hepatitis C

A Ulsenheimer, JT Gerlach, NH Gruener, MC Jung… - Hepatology, 2003 - Elsevier
Chronic hepatitis C is characterized by a weak or absent hepatitis C virus (HCV)-specific
CD4+ T-cell response in terms of antigen-specific proliferation or interferon gamma (IFN-γ) …

Prospective study of viral clearance and CD4+ T-cell response in acute hepatitis C primary infection and reinfection

JH Aberle, E Formann, P Steindl-Munda… - Journal of clinical …, 2006 - Elsevier
BACKGROUND: The outcome of acute hepatitis C is determined by early host–virus
interactions, particularly involving the antiviral T-cell response. OBJECTIVES: To identify …

Role of the specific T‐cell response for clearance and control of hepatitis C virus

GR Pape, TJ Gerlach, HM Diepolder… - Journal of viral …, 1999 - Wiley Online Library
T cells are believed to be the main players in antiviral defence. To investigate the role of the
specific CD4+ T cell response for clearance and control of the hepatitis C virus we studied …

[PDF][PDF] Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C

AL Cox, T Mosbruger, GM Lauer, D Pardoll… - …, 2005 - Wiley Online Library
We comprehensively studied the cellular immune response during acute human hepatitis C
virus (HCV) infection by monthly prospective sampling of persons at high risk of infection. In …