Systemic administration of minocycline inhibits formalin-induced inflammatory pain in rat
It has been demonstrated that spinal microglial activation is involved in formalin-induced
pain and that minocycline, an inhibitor of microglial activation, attenuate behavioral …
pain and that minocycline, an inhibitor of microglial activation, attenuate behavioral …
Minocycline prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms
SSV Padi, SK Kulkarni - European journal of pharmacology, 2008 - Elsevier
Glia, particularly astrocytes and microglia, are known to play an important role in central
sensitization and are strongly implicated in the exaggerated pain states. In the present study …
sensitization and are strongly implicated in the exaggerated pain states. In the present study …
A minocycline derivative reduces nerve injury-induced allodynia, LPS-induced prostaglandin E2 microglial production and signaling via toll-like receptors 2 and 4
LFS Bastos, AM Godin, Y Zhang, S Jarussophon… - Neuroscience …, 2013 - Elsevier
Many studies have shown that minocycline, an antibacterial tetracycline, suppresses
experimental pain. While minocycline's positive effects on pain resolution suggest that …
experimental pain. While minocycline's positive effects on pain resolution suggest that …
Minocycline inhibits neurogenic inflammation by blocking the effects of tumor necrosis factor‐α
It has been well established that neurogenic inflammation is one of the major pathological
processes underlying inflammatory pain, but there are few effective anti‐inflammatory drugs …
processes underlying inflammatory pain, but there are few effective anti‐inflammatory drugs …
Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation
A Ledeboer, EM Sloane, ED Milligan, MG Frank… - Pain, 2005 - Elsevier
Activated glial cells (microglia and astroglia) in the spinal cord play a major role in mediating
enhanced pain states by releasing proinflammatory cytokines and other substances thought …
enhanced pain states by releasing proinflammatory cytokines and other substances thought …
Intrathecal minocycline attenuates peripheral inflammation‐induced hyperalgesia by inhibiting p38 MAPK in spinal microglia
XY Hua, CI Svensson, T Matsui… - European Journal of …, 2005 - Wiley Online Library
Activation of p38 mitogen‐activated protein kinase (p38) in spinal microglia is implicated in
spinal nociceptive processing. Minocycline, a tetracycline derivative, displays selective …
spinal nociceptive processing. Minocycline, a tetracycline derivative, displays selective …
Analgesic effect of minocycline in rat model of inflammation-induced visceral pain
P Kannampalli, S Pochiraju, M Bruckert… - European journal of …, 2014 - Elsevier
The present study investigates the analgesic effect of minocycline, a semi-synthetic
tetracycline antibiotic, in a rat model of inflammation-induced visceral pain. Inflammation …
tetracycline antibiotic, in a rat model of inflammation-induced visceral pain. Inflammation …
Minocycline modulates neuropathic pain behaviour and cortical M1–M2 microglial gene expression in a rat model of depression
There is a paucity of data on the role of microglia and neuroinflammatory processes in the
association between chronic pain and depression. The current study examined the effect of …
association between chronic pain and depression. The current study examined the effect of …
Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy
V Raghavendra, F Tanga, JA DeLeo - Journal of Pharmacology and …, 2003 - ASPET
Microglia, the intrinsic macrophages of the central nervous system, have previously been
shown to be activated in the spinal cord in several rat mononeuropathy models. Activation of …
shown to be activated in the spinal cord in several rat mononeuropathy models. Activation of …
Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain
J Mika, M Osikowicz, W Makuch… - European journal of …, 2007 - Elsevier
Recent research has shown that microglial cells which are strongly activated in neuropathy
can influence development of allodynia and hyperalgesia. Here we demonstrated that …
can influence development of allodynia and hyperalgesia. Here we demonstrated that …