In addition to the central and spinal sites of action of morphine both our laboratory and
others have demonstrated that opiates can also cause analgesia through a peripheral …

The role of the L-arginine-NO-cGMP pathway in morphine-induced central analgesia was
investigated in two nociceptive tests: PGE 2-induced hind paw hyperalgesia and tail-flick …

Although the phenomenon of opioid tolerance has been widely investigated, neither opioid
nor nonopioid mechanisms are completely understood. The aim of the present study was to …

We have previously described the analgesic effect of dibutyryl cyclic GMP or acetylcholine
(ACh) injected into rat paws. Since ACh induces nitric oxide (NO) release from endothelial …

We tested the hypothesis that activation of the nitric oxide (NO)-cGMP pathway is involved in
the mechanism of two directly acting non-opiate peripheral analgesics, myrcene and …

The effect of inhibition of nitric oxide synthesis and guanylate cyclase on the peripheral
antinociceptive effect of morphine was assessed by using the formalin test in the rat. Saline …

Indomethacin, a typical cyclo-oxygenase inhibitor, acts as an analgesic by preventing the
hyperalgesia induced by prostaglandins during inflammation. Analgesics of the dipyrone …

The final step in the direct restoration of the nociceptor threshold by peripheral
administration of morphine and dipyrone was recently suggested to result from the opening …

L-Arginine (100-1000 mg kg-1) administered orally (po) or intraperitoneally (ip), but not
intracerebroventricularly (icv, 0.08 mg per mouse), reduced the antinociceptive effect of …

The objective of this study was to characterize further the nature of nitrous oxide analgesia
and to establish if tolerance to nitrous oxide occurs. Methods for studying the analgesic …