We have obtained via DNA sequence analysis a spectrum of 174 spontaneous mutations
occurring in the lacI gene of Escherichia coli. The spectrum comprised base substitution …

To gain more detailed insight into the nature and mechanisms of spontaneous mutations, we
undertook a DNA sequence analysis of a large collection of spontaneous mutations in the N …

This paper describes the DNA sequence analysis of 729 independent spontaneous lacI−
mutation This total is comprised of 478 novel mutations and 251 previously described …

A model is presented for deletion mutations whose formation is mediated by palindromic
and quasipalindromic DNA sequences. It proposes that the self-complementarity of …

To determine whether base-to-base variations in the rate of excision repair influence the
distribution of mutations, we have developed a method to measure UV photoproducts at …

A genetic and sequence analysis of 373 ICR-191-induced mutations in the lacI gene of
Escherichia coli reveals that 365 of the mutations (97· 9%) are frameshifts involving the …

Abstract 140 independently occurring spontaneous mutations in the lacI gene of Escherichia
coli have been examined genetically and physically. DNA sequence analysis of a genetic …

An extensive set of amber and ochre sites in the lacI gene has been characterized with
respect to the base change required to generate the nonsense codon (Miller et al., 1977; …

The spectrum of mutations induced by ionizing radiation (γ-rays) was determined in the lacI
gene of E. coli. Base substitution was the principal type of mutational event following …

Transgenic mice with a lambda shuttle vector containing a lacI target gene were generated
for use as a short-term, in vivo mutagenesis assay. The gene is recovered from the treated …