The molecular integration of poorly water soluble active pharmaceutical ingredients (APIs) in
a suitable polymeric matrix is a possible approach to enhance the dissolution behavior and …

Amorphous solid dispersions (ASDs) are often metastable against crystallization of the
active pharmaceutical ingredient (API) and thus might undergo unwanted changes during …

Amorphous phase separation (APS) is commonly observed in amorphous solid dispersions
(ASD) when exposed to moisture. The objective of this study was to investigate:(1) the phase …

Understanding and prevention of unwanted changes of a pharmaceutical formulation during
the production process is part of the critical requirements for the successful approval of a …

Abstract Formulation of an amorphous solid dispersion (ASD) is one of the methods
commonly considered to increase the bioavailability of a poorly water-soluble small …

Amorphous solid dispersions (ASDs) are often used for formulating poorly water-soluble
active pharmaceutical ingredients (APIs). In an ASD, the amorphous API is embedded in a …

Amorphous solid dispersions (ASDs) of a poorly water-soluble active pharmaceutical
ingredient (API) in a polymer matrix can enhance the water solubility and therefore generally …

Polymers like poly (vinylpyrrolidone-co-vinyl acetate)(PVPVA) or hydroxypropyl
methylcellulose acetate succinate (HPMCAS) are commonly used as a matrix for amorphous …

Amorphous solid dispersions (ASDs), where an active pharmaceutical ingredient (API) is
dissolved in a polymer, are a favored formulation technique to achieve sufficient …

The bioavailability of poorly-water-soluble active pharmaceutical ingredients (APIs) can be
significantly improved by so-called amorphous solid dispersions (ASDs). However, the long …