Reduced levels of global DNA methylation are associated with genomic instability and are
independent predictors of cancer risk. Little is known about the environmental determinants …

Changes in DNA methylation may represent an intermediate step between the environment
and human diseases. Little is known on whether behavioral risk factors may modify gene …

One plausible mechanism for the environment to alter cancer susceptibility is through DNA
methylation. Alterations in DNA methylation can lead to genomic instability and altered gene …

Altered levels of global DNA methylation and gene silencing through methylation of
promoter regions can impact cancer risk, but little is known about their environmental …

Alterations in DNA methylation patterns, both at specific loci and overall in the genome, have
been associated with many different health outcomes. In cancer and other diseases, most of …

Background: Lower levels of global DNA methylation in tissue and blood have been
associated with increased cancer risk. Conversely, cross-sectional analyses of healthier …

Aberrant DNA methylation is associated with cancer development and progression. There
are several types of specimens from which DNA methylation pattern can be measured and …

Background Good biomarkers for early detection of cancer lead to better prognosis.
However, harvesting tumor tissue is invasive and cannot be routinely performed. Global …

Background Estimates of global DNA methylation from repetitive DNA elements, such as Alu
and LINE-1, have been increasingly used in epidemiological investigations because of their …

Animal studies have provided direct evidence that dietary factors induce changes in DNA
methylation patterns. In humans, studies on diet and DNA methylation have yielded …