Trisomy 21, the presence of a supernumerary chromosome 21, results in a collection of
clinical features commonly known as Down syndrome (DS). DS is among the most …

Down syndrome (DS) is the most common aneuploidy of chromosome 21, characterized by
the presence of an extra copy of that chromosome (trisomy 21). Children with DS present …

Down syndrome (DS) has been recognized as a clinical entity for about 150 years, but it is
only recently that there has been hope for the possibility to understand its pathogenesis and …

Even though the molecular mechanisms underlying the Down syndrome (DS) phenotypes
remain obscure, the characterization of the genes and conserved non-genic sequences of …

Down syndrome (DS), or trisomy 21, is a common disorder associated with several complex
clinical phenotypes. Although several hypotheses have been put forward, it is unclear as to …

During the last years, Down syndrome has been the focus of special attention. Down
syndrome is a genetic disorder characterized by distinct physical features and some degree …

Trisomy 21 or Down syndrome is a chromosomal disorder resulting from the presence of all
or part of an extra Chromosome 21. It is a common birth defect, the most frequent and most …

Background Down syndrome (DS) is caused by trisomy 21 (+ 21), but the aberrations in
gene expression resulting from this chromosomal aneuploidy are not yet completely …

Down syndrome (also known as trisomy 21) is the model human phenotype for all genomic
gain dosage imbalances, including microduplications. The functional genomic exploration of …

Virtually all adults with Down syndrome (DS) show the neuropathological changes of
Alzheimer disease (AD) by the age of 40 years. This association is partially due to …