Myostatin is a negative regulator of muscle growth. Loss of myostatin has been shown to
cause increase in skeletal muscle size and improve skeletal muscle function and fibrosis in …

Myostatin, a transforming growth factor–β family member, is a negative regulator of skeletal
muscle growth. To explore the therapeutic potential of targeting myostatin in settings of …

Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining
both muscle fiber number and size. The myostatin pathway is conserved and regulates …

Genetic deletion of Myostatin, a member of the Transforming Growth Factor-beta family of
signalling molecules, resulted in excessive growth of skeletal muscle. It demonstrated the …

Abstract Background Myostatin (Mstn) is a negative regulator of muscle growth whose
inhibition promotes muscle growth and regeneration. Dystrophin-deficient mdx mice in …

Myostatin is an endogenous inhibitor of muscle conserved across diverse species. In the
absence of myostatin, there is massive muscle growth in mice, cattle, and humans. Previous …

Mutations in the myostatin gene are associated with hypermuscularity, suggesting that
myostatin inhibits skeletal muscle growth. We postulated that increased tissue-specific …

Background—Cardiac cachexia is characterized by an exaggerated loss of skeletal muscle,
weakness, and exercise intolerance, although the cause of these effects remains unknown …

In 1997, McPherron et al. created the so-called Mighty Mouse: owing to the knock-out of a
new member of the TGF-β superfamily of peptides, this mouse line was extremely …

A significant proportion of heart failure patients develop skeletal muscle wasting and cardiac
cachexia, which is associated with a very poor prognosis. Recently, myostatin, a cytokine …