Nrf1 is a member of the vertebrate Cap'n'Collar (CNC) transcription factor family that
commonly contains a unique basic-leucine zipper domain. Among CNC family members …

Background Nrf2 belongs to the Cap‐N‐Collar (CNC) transcription factor family and is
essential for the antioxidant responsive element (ARE)‐mediated expression of a group of …

Oxidative stress plays an important part in the pathogenesis of a variety of diseases. The
ability to mount an efficient response against the continuous threat posed by exogenous and …

Transcription factor Nrf2 is considered a master regulator of antioxidant defense in
mammals. However, it is unclear whether this concept is applicable to nonmammalian …

Expression of antioxidant and phase 2 xenobiotic metabolizing enzyme genes is regulated
through cis-acting sequences known as antioxidant response elements. Transcriptional …

ABSTRACT NF‐E2‐related factor 2 (Nrf2) is a basic leucine zipper transcription factor that
binds to the promoter sequence “antioxidant responsive element (ARE)” leading to …

The antioxidant responsive element (ARE) is a cis-acting regulatory element of genes
encoding phase II detoxification enzymes and antioxidant proteins, such as NAD (P) H …

Transcription factor NF-E2-related factor 2 (Nrf2) belongs to the basic region-leucine zipper
family and is activated in response to electrophiles and reactive oxygen species. Nrf2 …

Nrf1 is a member of the CNC-basic leucine zipper (CNC-bZIP) family of transcription factors.
CNC bZIP factors, together with small Maf proteins, bind as heterodimers to the NF-E2/AP-1 …

Knockout studies have shown that the transcription factor Nrf1 is essential for embryonic
development. Nrf1 has been implicated to play a role in mediating activation of oxidative …