Role of Dectin-2 in the phagocytosis of Cryptococcus neoformans by dendritic cells

Y Kitai, K Sato, D Tanno, X Yuan, A Umeki… - Infection and …, 2021 - Am Soc Microbiol
The cell walls and capsules of Cryptococcus neoformans, a yeast-type fungal pathogen, are
rich in polysaccharides. Dectin-2 is a C-type lectin receptor (CLR) that recognizes high …

Dectin‐2‐mediated signaling triggered by the cell wall polysaccharides of Cryptococcus neoformans

D Tanno, R Yokoyama, K Kawamura… - Microbiology and …, 2019 - Wiley Online Library
Cryptococcus neoformans is rich in polysaccharides of the cell wall and capsule. Dectin‐2
recognizes high‐mannose polysaccharides and plays a central role in the immune response …

Dectin-2 deficiency promotes Th2 response and mucin production in the lungs after pulmonary infection with Cryptococcus neoformans

Y Nakamura, K Sato, H Yamamoto… - Infection and …, 2015 - Am Soc Microbiol
Dectin-2 is a C-type lectin receptor that recognizes high mannose polysaccharides.
Cryptococcus neoformans, a yeast-form fungal pathogen, is rich in polysaccharides in its cell …

Characterization of C-type lectins reveals an unexpectedly limited interaction between Cryptococcus neoformans spores and Dectin-1

NM Walsh, M Wuthrich, H Wang, B Klein, CM Hull - PLoS One, 2017 - journals.plos.org
Phagocytosis by innate immune cells is an important process for protection against multiple
pathologies and is particularly important for resistance to infection. However, phagocytosis …

Dectin-3 Is Not Required for Protection against Cryptococcus neoformans Infection

A Campuzano, N Castro-Lopez, KL Wozniak… - PLoS …, 2017 - journals.plos.org
C-type lectin receptors (CLRs) are diverse, trans-membrane proteins that function as pattern
recognition receptors (PRRs) which are necessary for orchestrating immune responses …

Dectin‐1 Is Not Required for the Host Defense to Cryptococcus neoformans

K Nakamura, T Kinjo, S Saijo… - Microbiology and …, 2007 - Wiley Online Library
Dectin‐1 is known as a sole receptor for β‐glucan, a major cell wall component of fungal
microorganisms. In the current study, we examined the role of this molecule in the host …

Dectin-2 recognition of α-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans

S Saijo, S Ikeda, K Yamabe, S Kakuta, H Ishigame… - Immunity, 2010 - cell.com
Summary Dectin-2 (gene symbol Clec4n) is a C-type lectin expressed by dendritic cells
(DCs) and macrophages. However, its functional roles and signaling mechanisms remain to …

Phospholipase Cγ2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells

S Xu, J Huo, KG Lee, T Kurosaki, KP Lam - Journal of Biological Chemistry, 2009 - ASBMB
Dectin-1 is a C-type lectin that recognizes β-glucan in the cell walls of fungi and plays an
important role in anti-fungal immunity. It signals via tyrosine kinase Syk and adaptor protein …

The induction of inflammation by dectin-1 in vivo is dependent on myeloid cell programming and the progression of phagocytosis

M Rosas, K Liddiard, M Kimberg… - The Journal of …, 2008 - journals.aai.org
Dectin-1 is the archetypal signaling, non-Toll-like pattern recognition receptor that plays a
protective role in immune defense to Candida albicans as the major leukocyte receptor for β …

Dectin-1 escape by fungal dimorphism

SEM Heinsbroek, GD Brown, S Gordon - Trends in immunology, 2005 - cell.com
Candida albicans, a medically important fungus, exists primarily as yeast and filamentous
forms. Its cell wall is rich in β-glucans, which are recognized by a lectin-like innate immune …