Tachykinin receptor antagonists inhibit hyperpnea-induced bronchoconstriction in guinea pigs.
J Solway, BM Kao, JE Jordan, B Gitter… - The Journal of …, 1993 - Am Soc Clin Investig
We tested the hypothesis that hyperpnea-induced bronchoconstriction (HIB) and hyperpnea-
induced bronchovascular hyperpermeability (HIBVH) are mediated through stimulation of …
induced bronchovascular hyperpermeability (HIBVH) are mediated through stimulation of …
In vivo characterization of the tachykinin receptors involved in the direct and indirect bronchoconstrictor effect of tachykinins in two inbred rat strains.
GF Joos, JC Kips, RA Pauwels - American journal of respiratory and …, 1994 - atsjournals.org
Three receptors for the tachykinins, NK1, NK2, and NK3, have been defined
pharmacologically and have been cloned. We previously demonstrated that in Fisher 344 …
pharmacologically and have been cloned. We previously demonstrated that in Fisher 344 …
Differential blockade by tachykinin NK1 and NK2 receptor antagonists of bronchoconstriction induced by direct-acting agonists and the indirect-acting mimetics …
CK Buckner, N Liberati, D Dea, D Lengel… - … of Pharmacology and …, 1993 - ASPET
This study has examined the abilities of (+/-)-CP96345 and (+/-)-SR48968, nonpeptide
antagonists selective for the tachykinin NK1 and NK2 receptors, respectively, to block …
antagonists selective for the tachykinin NK1 and NK2 receptors, respectively, to block …
Mediators in hyperpnea-induced bronchoconstriction of guinea pigs
YL Lai, SP Lee - Naunyn-Schmiedeberg's archives of pharmacology, 1999 - Springer
Both tachykinins and leukotrienes (LTs) have been demonstrated to be the mediators for
hyperpnea-induced bronchoconstriction (HIB) of guinea pigs. We tested the hypothesis that …
hyperpnea-induced bronchoconstriction (HIB) of guinea pigs. We tested the hypothesis that …
Tachykinins mediate bronchoconstriction elicited by isocapnic hyperpnea in guinea pigs
DW Ray, C Hernandez, AR Leff… - Journal of Applied …, 1989 - journals.physiology.org
We tested the hypothesis that tachykinins mediate hyperpnea-induced bronchoconstriction
(HIB) in 28 guinea pigs. Stimulus-response curves to increasing minute ventilation with dry …
(HIB) in 28 guinea pigs. Stimulus-response curves to increasing minute ventilation with dry …
Neurokinins modulate hyperventilation-induced bronchoconstriction in canine peripheral airways
AN Freed, S McCulloch, T Meyers… - American journal of …, 2003 - atsjournals.org
This study was designed to test the hypotheses that (1) neurokinin (NK) receptor activity
modulates hyperventilation-induced bronchoconstriction (HIB) in canine peripheral airways …
modulates hyperventilation-induced bronchoconstriction (HIB) in canine peripheral airways …
Characterization of NK1 and NK2 tachykinin receptors in guinea‐pig and rat bronchopulmonary and vascular systems
A Floch, V Fardin, I Cavero - British journal of pharmacology, 1994 - Wiley Online Library
1 NK1 and NK2 tachykinin receptors were characterized in guinea‐pig and rat
bronchopulmonary systems and in the vasculature of the rat by use of radioligand binding …
bronchopulmonary systems and in the vasculature of the rat by use of radioligand binding …
Tachykinin NK1 and NK2 receptors mediate the non-cholinergic bronchospastic response to capsaicin and vagal stimulation in guinea-pigs.
P Boni, L Ballati, S Evangelista - Journal of Autonomic …, 1995 - europepmc.org
1. The antibronchospastic activity against acetylcholine, capsaicin, electrical vagal
stimulation and the selective tachykinin agonists ([beta Ala8] NKA-(4-10) and [Sar9] SP …
stimulation and the selective tachykinin agonists ([beta Ala8] NKA-(4-10) and [Sar9] SP …
Role of nitric oxide and septide‐insensitive NK1 receptors in bronchoconstriction induced by aerosolised neurokinin A in guinea‐pigs
FLM Ricciardolo, M Trevisani, P Geppetti… - British journal of …, 2000 - Wiley Online Library
The tachykinin, neurokinin A (NKA), contracts guinea‐pig airways both in vitro and in vivo,
preferentially activating smooth muscle NK2 receptors, although smooth muscle NK1 …
preferentially activating smooth muscle NK2 receptors, although smooth muscle NK1 …
Neurokinin B‐ and specific tachykinin NK3 receptor agonists‐induced airway hyperresponsiveness in the guinea‐pig
S Daoui, E Naline, V Lagente… - British journal of …, 2000 - Wiley Online Library
The aim of this study was to determine whether neurokinin B (NKB) or specific agonists of
tachykinin NK3 receptors,[MePhe7] NKB and senktide, were able to induce airway …
tachykinin NK3 receptors,[MePhe7] NKB and senktide, were able to induce airway …