We tested the hypothesis that hyperpnea-induced bronchoconstriction (HIB) and hyperpnea-
induced bronchovascular hyperpermeability (HIBVH) are mediated through stimulation of …

Three receptors for the tachykinins, NK1, NK2, and NK3, have been defined
pharmacologically and have been cloned. We previously demonstrated that in Fisher 344 …

This study has examined the abilities of (+/-)-CP96345 and (+/-)-SR48968, nonpeptide
antagonists selective for the tachykinin NK1 and NK2 receptors, respectively, to block …

Both tachykinins and leukotrienes (LTs) have been demonstrated to be the mediators for
hyperpnea-induced bronchoconstriction (HIB) of guinea pigs. We tested the hypothesis that …

We tested the hypothesis that tachykinins mediate hyperpnea-induced bronchoconstriction
(HIB) in 28 guinea pigs. Stimulus-response curves to increasing minute ventilation with dry …

This study was designed to test the hypotheses that (1) neurokinin (NK) receptor activity
modulates hyperventilation-induced bronchoconstriction (HIB) in canine peripheral airways …

1 NK1 and NK2 tachykinin receptors were characterized in guinea‐pig and rat
bronchopulmonary systems and in the vasculature of the rat by use of radioligand binding …

1. The antibronchospastic activity against acetylcholine, capsaicin, electrical vagal
stimulation and the selective tachykinin agonists ([beta Ala8] NKA-(4-10) and [Sar9] SP …

The tachykinin, neurokinin A (NKA), contracts guinea‐pig airways both in vitro and in vivo,
preferentially activating smooth muscle NK2 receptors, although smooth muscle NK1 …

The aim of this study was to determine whether neurokinin B (NKB) or specific agonists of
tachykinin NK3 receptors,[MePhe7] NKB and senktide, were able to induce airway …