Melanocyte and retinal pigment epithelium (RPE) specifically express tyrosinase and other
melanin‐producing enzymes. Microphthalmia‐associated transcription factor (Mitf), encoded …

Microphthalmia (MITF) gene product, a transcription factor of the basic-helix-loop-helix type,
is thought to play a role in the regulation of genes encoding the enzymes necessary for …

The microphthalmia transcription factor MITF plays important roles in several cell lineages
including retinal and neural crest‐derived pigment cells. Previous reports have shown that …

Mitf encodes a basic helix-loop-helix transcription factor that plays an essential role in the
differentiation of the retinal pigmented epithelium (RPE) and neural crest-derived …

MITF mutations results in an abnormal melanocyte development and lead to Waardenburg
syndrome type 2 (WS2). Here, we analyzed the in vitro activities of two recently identified …

Microphthalmia is a developmental eye defect that is highly variable in severity and in its
potential for systemic association. Despite the discovery of many disease genes in …

The ability of transcription factors to discriminate between different classes of binding sites
associated with specific biological functions underpins effective gene regulation in …

In the melanocyte, expression of genes required for pigment formation is mediated by the
microphthalmia transcription factor, which is also critical for the development and survival of …

α-Melanocyte-stimulating hormone (MSH) utilizes cAMP to trigger pigmentation of
melanocytes via activation of melanocyte-restricted microphthalmia-associated transcription …

Dysfunction and loss of the retinal pigment epithelium (RPE) are hallmarks of retinal
degenerative diseases in mammals. A critical transcription factor for RPE development and …