Interleukin-7 (IL-7) is a homeostatic cytokine for resting T cells with increasing serum and
tissue levels during T cell depletion. In preclinical studies, IL-7 therapy exerts marked …

Recent evidence has implicated interleukin-7 (IL-7) as a master regulator of T-cell
homeostasis, based upon its essential role in the homeostatic expansion of naive T-cell …

ABSTRACT Interleukin-7 (IL-7) regulates T-cell homeostasis, and its availability is
augmented in lymphopenic hosts. Naive CD8+ T cells transferred to lymphopenic mice …

Abstract Interleukin-7 (IL-7) is required for T cell development and for maintaining and
restoring homeostasis of mature T cells. IL-7 is a limiting resource under normal conditions …

Interleukin-7 (IL-7) is important for thymopoiesis in mice and humans because IL-7 receptor
α (IL-7Rα) mutations result in a severe combined immunodeficiency phenotype with severe …

IL-7 is vital for the development of the immune system and profoundly enhances the function
of mature T cells. Chronic administration of IL-7 to mice markedly increases T cell numbers …

Thymic-deficient hosts rely primarily on antigen-driven expansion to restore the peripheral T-
cell compartment following T-cell depletion (TCD). The degree to which this thymic …

During an immune response, peripheral T-cell populations expand and then contract as the
response subsides, thus maintaining a fairly constant number of CD4 and CD8 T cells …

Interleukin (IL)-7 is a cytokine essential for T lymphocyte development and homeostasis.
However, little is known about the roles of IL-7 receptor α-chain (IL-7Rα) in late stages of T …

IL-7 is well known as a lymphopoietic cytokine, but recent studies have also identified a
critical role for IL-7 in peripheral T cell homeostasis. IL-7 is well poised to serve as a …