OBJECTIVE ACTH is secreted by the pituitary following processing of larger molecular
weight precursors, proopiomelanocortin and pro‐ACTH. Ectopic ACTH syndrome refers to …

A major cause of Cushing's syndrome is the production of biologically active ACTH by a
cancer. Most often the neoplasm is obviously the cause, but in some patients with subtle …

In recent years the techniques of molecular and cellular biology have made it possible to
begin to dissect the origins and behaviour of the ACTH‐secreting tumour cell. It is becoming …

Ectopic ACTH syndrome represents a cancer-induced amplification of a property
[proopiomelanocortin (POMC) peptides production] normally present in the cells from which …

Adrenocorticotrophin (ACTH) is derived by cleavage from the precursor, pro-
opiomelanocortin (POMC), and depending on the degree of processing by the tissue or …

There are roughly two types of ectopic ACTH syndrome (EAS), one associated with overt
malignancies and one with occult neoplasms. The prototype of the first condition is …

Evidence was found for the existence of four tumor peptides with corticotropin-releasing-
factor-like (CRF) activity, two isolated from a pancreatic tumor (P-CRF-1, P-CRF-2) and two …

Despite all we have learnt, the reason why certain tumours and particularly non-pituitary
tumours synthesize ACTH remains an enigma. There is no clear theory which links the …

An immunoradiometric assay (IRMA) for the direct measurement of the precursors of ACTH
in unextracted human plasma has been developed and evaluated clinically in normal …

Extracts of tumors from 32 patients with the ectopic ACTH syndrome were subjected to
simultaneous bioassay and radioimmunoassays for ACTH. Radioimmunoassays were …