Adaptive T-cell immunotherapy holds great promise for the successful treatment of leukemia,
as well as other types of cancers. More recently, it was also shown to be an effective …

Recent advances in the development of gene editing technologies, especially the
CRISPR/Cas 9 system, have substantially enhanced our ability to make precise and efficient …

Cancer immunotherapy has been emerged as a promising strategy for treatment of a broad
spectrum of malignancies ranging from hematological to solid tumors. One of the principal …

While clustered regularly interspaced short palindromic repeats (CRISPR)-based genome
editing techniques have been widely adapted for use in immortalised immune cells, efficient …

Cancer patients have been treated with various types of therapies, including conventional
strategies like chemo‐, radio‐, and targeted therapy, as well as immunotherapy like …

Engineering human T cells for the treatment of cancer, viral infections and autoimmunity has
been a long-standing dream of many immunologists and hematologists. Although primary …

CRISPR (clustered, regularly interspaced, short palindromic repeats)/Cas9 (CRISPR-
associated protein 9) has become the tool of choice for generating gene knockouts across a …

The development of genome editing tools capable of modifying specific genomic sequences
with unprecedented accuracy has opened up a wide range of new possibilities in targeted …

Chimeric antigen receptor (CAR) T cells have shown great promise in the treatment of
hematological and solid malignancies. However, despite the success of this field, there …

CRISPR/Cas9 technologies have revolutionized our understanding of gene function in
complex biological settings, including T cell immunology. Current CRISPR-mediated gene …