Thyroxine, the major secretory product of the thyroid gland, is metabolized in the peripheral
tissues by phenolic conjugation, deamination, decarboxylation, and a cascade of …

The butterfly-shaped thyroid gland, sitting at the base of the neck just below the larynx,
influences basic metabolism, heart rate, blood pressure, and body temperature, among …

Publisher Summary This chapter explores the metabolic pathways of thyroid hormones. In
vitro studies have been employed to study the nature of this peripheral regulatory …

The major thyroid hormone (TH) secreted by the thyroid gland is thyroxine (T4).
Triiodothyronine (T3), formed chiefly by deiodination of T4, is the active hormone at the …

Thyroid hormone production is regulated via pituitary thyrotropin (TSH) modulation of
thyroxine (T4) prohormone secretion by the thyroid gland and regulation of active …

T HYROIDAL secretion is the only source of thyroxine (T4) in the human systemic circulation,
and in euthyroid man, T4 is the main secretory product of the gland. The metabolic fate of the …

A particulate fraction of rat thyroid gland sedimenting between 1,500–100,000× g contains
enzymatic activities that catalyze the sequential deiodination of T4 to 3, 3′-diiodothyronine …

The thyroid gland of healthy adults secretes approximately 78 p, g (100 nmole) thyroxine
(T4) per day. Of this, about 80 nmole undergo deiodination in extrathyroi dal sites. The …

There is growing evidence that environmental chemicals can disrupt endocrine systems.
Most evidence originates from studies on reproductive organs. However, there is also …

The enzymatic conversion of thyroxine into the more potent biological compound, 3, 3′, 5-
tri-iodothyronine (T 3), takes place in many tissues and requires thiols. Reduced glutathione …