Myostatin, a member of the TGF-β family, has been identified as a powerful inhibitor of
muscle growth. Absence or blockade of myostatin induces massive skeletal muscle …

Key points• There is disagreement about whether muscle hypertrophy requires the activation
and fusion of satellite cells, the quiescent muscle stem cells, to the multinucleated post …

Myostatin, a TGF-β family member, is a negative regulator of muscle growth. Here, we
generated transgenic mice that expressed myostatin mutated at its cleavage site under the …

Myostatin, a TGF-β family member, is an important regulator of adult muscle size. While
extensively studied in vitro, the mechanisms by which this molecule mediates its effect in …

Increasing the size and strength of muscles represents a promising therapeutic strategy for
musculoskeletal disorders, and interest has focused on myostatin, a negative regulator of …

Myostatin is an endogenous, negative regulator of muscle growth determining both muscle
fiber number and size. The myostatin pathway is conserved across diverse species ranging …

Myostatin, or GDF-8 (growth and differentiation factor-8), was first identified through
sequence identity with members of the BMP (bone morphogenetic protein)/TGF-β …

Myostatin deficiency leads in skeletal muscle overgrowth but the precise molecular
mechanisms underlying this hypertrophy are not well understood. In this study, to gain …

A human therapeutic that specifically modulates skeletal muscle growth would potentially
provide a benefit for a variety of conditions including sarcopenia, cachexia, and muscular …

The lack of myostatin promotes growth of skeletal muscle, and blockade of its activity has
been proposed as a treatment for various muscle-wasting disorders. Here, we have …