In contrast to the detailed understanding we have for the regulation of skeletal muscle gene
expression in embryos, similar insights into postnatal muscle growth and regeneration are …

Myostatin is a secreted growth and differentiation factor that belongs to the TGF‐β
superfamily. Myostatin is predominantly synthesized and expressed in skeletal muscle and …

▪ Abstract Myostatin is a secreted protein that acts as a negative regulator of skeletal muscle
mass. During embryogenesis, myostatin is expressed by cells in the myotome and in …

Muscle growth results from a set of complex processes including myogenic transcription
factor's expression and activity, cell cycle withdrawal, myoblast fusion in myotubes, and …

Myostatin (MSTN) is a transforming growth factor-β (TGF-β) family member that normally acts
to limit muscle growth. The function of MSTN is partially redundant with that of another TGF-β …

Myostatin (MSTN) is a member of the transforming growth factor-β superfamily of cytokines
and is a negative regulator of skeletal muscle mass. Compared with MSTN+/+ mice, the …

Inactivating mutations of the mammalian myostatin gene are associated with increased
muscle mass and decreased fat mass; conversely, myostatin transgenic mice that …

Myostatin is a secreted protein that normally acts to limit skeletal muscle growth. As a result,
there is considerable interest in developing agents capable of blocking myostatin activity, as …

Myostatin mutations in mice and cattle are associated with increased muscularity,
suggesting that myostatin is a negative regulator of skeletal muscle mass. To test the …

Skeletal muscle possesses the ability to both respond and adapt to changing environmental
stimuli, leading to a set of metabolic and morphological adaptations, which allow it to better …