Toll-like receptor 2 ligands promote chronic atopic dermatitis through IL-4–mediated suppression of IL-10

S Kaesler, T Volz, Y Skabytska, M Köberle… - Journal of Allergy and …, 2014 - Elsevier
Background Atopic dermatitis (AD) is a T cell–mediated inflammatory skin disease, with TH 2
cells initiating acute flares. This inflamed skin is immediately colonized with Staphylococcus …

Effects of the Staphylococcus aureus and Staphylococcus epidermidis Secretomes Isolated from the Skin Microbiota of Atopic Children on CD4+ T Cell Activation

E Laborel-Préneron, P Bianchi, F Boralevi, P Lehours… - PLoS …, 2015 - journals.plos.org
Interactions between the immune system and skin bacteria are of major importance in the
pathophysiology of atopic dermatitis (AD), yet our understanding of them is limited. From a …

Contribution of IL-18 to atopic-dermatitis-like skin inflammation induced by Staphylococcus aureus product in mice

M Terada, H Tsutsui, Y Imai, K Yasuda… - Proceedings of the …, 2006 - National Acad Sciences
Atopic dermatitis (AD) is a common inflammatory skin disease of unknown etiology.
Cutaneous infection with microbes such as Staphylococcus aureus and/or skin cleansing …

Increased Th2 activity and diminished skin barrier function cooperate in allergic skin inflammation

S Sehra, P Krishnamurthy, B Koh… - European journal of …, 2016 - Wiley Online Library
Atopic dermatitis (AD) is a chronic inflammatory skin disease induced by a complex
interaction between susceptibility genes encoding skin barrier components and …

Exploring the Role of Staphylococcus Aureus Toxins in Atopic Dermatitis

F Seiti Yamada Yoshikawa, J Feitosa De Lima… - Toxins, 2019 - mdpi.com
Atopic dermatitis (AD) is a chronic and inflammatory skin disease with intense pruritus and
xerosis. AD pathogenesis is multifactorial, involving genetic, environmental, and …

T regulatory cells in atopic dermatitis and subversion of their activity by superantigens

LS Ou, E Goleva, C Hall, DYM Leung - Journal of Allergy and Clinical …, 2004 - Elsevier
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease involving
colonization by superantigen (SAg)–secreting Staphylococcus aureus. CD4+ CD25+ T …

Comparative immunophenotyping of monocytes from symptomatic and asymptomatic atopic individuals

D Von Bubnoff, M Scheler, T Hinz, H Matz, S Koch… - Allergy, 2004 - Wiley Online Library
Background: Allergy has at least two components–a genetic predisposition referred to as
atopy and the progress from an atopic state to clinically apparent disease. Peripheral blood …

Regulation of T cell immunity in atopic dermatitis by microbes: the yin and yang of cutaneous inflammation

T Biedermann, Y Skabytska, S Kaesler… - Frontiers in …, 2015 - frontiersin.org
Atopic dermatitis (AD) is a chronic inflammatory skin disease predominantly mediated by T
helper cells. While numerous adaptive immune mechanisms in AD pathophysiology have …

Bacterial and viral infections in atopic dermatitis: a comprehensive review

PY Ong, DYM Leung - Clinical reviews in allergy & immunology, 2016 - Springer
Atopic dermatitis (AD) is the most common allergic skin disease in the general population. It
is a chronic inflammatory skin disease complicated by recurrent bacterial and viral infections …

Scavenger receptor-specific allergen delivery elicits IFN-γ-dominated immunity and directs established TH2-dominated responses to a nonallergic phenotype

S Bhatia, S Mukhopadhyay, E Jarman, G Hall… - Journal of allergy and …, 2002 - Elsevier
Background: Immunotherapeutic approaches to allergy consist of reliably changing allergen-
specific TH2 immunity associated with secretion of IL-4, IL-5, and IL-13, along with IgE …