Resolution of hepatitis B virus (HBV) infection was believed to be attributed to the cytotoxic T
cell–mediated killing of infected hepatocytes. However, studies in HBV transgenic mice and …

Hepatitis B virus (HBV) is a noncytopathic virus, and the recognition of infected hepatocytes
by HBV-specific CD8 cells has been assumed to be the central mechanism causing both …

To understand the role of cytotoxic T cells in liver damage and viral control, we used human
histocompatibility leukocyte antigen (HLA)-peptide tetramers that allow direct ex vivo …

Clearance of the hepatitis B virus (HBV), a noncytopathic double-stranded DNA virus,
requires the coordinated response of innate and adaptive, humoral and cellular immune …

Although the CD4+-and CD8+-T-cell responses to the hepatitis B virus (HBV) are thought to
be crucial for the control of HBV infection, the relative contribution of each T-cell subset as …

The aim of this study was to elucidate the molecular basis for viral clearance and liver
disease in the pathogenesis of hepatitis B virus (HBV) infection. Using transgenic mice that …

ABSTRACT CD8 T cells exert their antiviral function through cytokines and lysis of infected
cells. Because hepatocytes are susceptible to noncytolytic mechanisms of viral clearance …

The adaptive immune response, particularly the virus‐specific CD8+ T‐cell response, is
largely responsible for viral clearance and disease pathogenesis during hepatitis B virus …

It is widely believed that viral clearance is mediated principally by the destruction of infected
cells by CTLs. In this report, we use a transgenic mouse model of HBV replication to …

Background & Aims: Cytotoxic T cells have been suggested to be responsible for lysis of
hepatitis B virus (HBV)-infected hepatocytes and control of virus infection. The frequency …