Background—Electrical, structural, and Ca2+-handling remodeling contribute to the
perpetuation/progression of atrial fibrillation (AF). Recent evidence has suggested a role for …

Although atrial fibrillation (AF) is the most commonly encountered cardiac arrhythmia, the
basic mechanisms underlying this disorder remain incompletely understood. During the past …

Atrial fibrillation (AF) is characterized by sustained high atrial activation rates and
arrhythmogenic cellular Ca2+ signaling instability; however, it is not clear how a high atrial …

Rationale: Persistent atrial fibrillation (AF) has been associated with structural and electric
remodeling and reduced contractile function. Objective: To unravel mechanisms underlying …

OBJECTIVES Our purpose was to determine whether atrial fibrillation (AF) patients have
alterations in sarcoplasmic reticulum (SR) Ca2+ regulatory proteins in the atrial myocardium …

Atrial fibrillation (AF) is the most prevalent sustained arrhythmia. As the most important risk
factor for embolic stroke, AF is associated with a high morbidity and mortality. Despite …

Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with
substantial morbidity and mortality. It causes profound changes in sarcoplasmic reticulum …

Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …

OBJECTIVES We investigated the gene expression of calcium-handling genes including L-
type calcium channel, sarcoplasmic reticular calcium adenosine triphosphatase (Ca2+ …

DR Van Wagoner and JM Nerbonne. Molecular Basis of Electrical Remodeling in Atrial
Fibrillation. Journal of Molecular and Cellular Cardiology (2000) 32, 1101–1117. Atrial …