On expanding the repertoire of glycosynthases: mutant β-galactosidases forming β-(1, 6)-linkages
DL Jakeman, SG Withers - Canadian journal of chemistry, 2002 - cdnsciencepub.com
Oligosaccharide synthesis by enzymatic processes offers the potential for thrusting
oligosaccharides to the forefront of pharmaceutical research, in part, due to expedient and …
oligosaccharides to the forefront of pharmaceutical research, in part, due to expedient and …
Preparation of oligosaccharide units library and its utilization
T Murata, T Usui - Bioscience, biotechnology, and biochemistry, 1997 - academic.oup.com
There is high current interest in developing synthetic routes to oligosaccharides involved in
glycoconjugates. Significant attention has been focused on the application of glycosidase …
glycoconjugates. Significant attention has been focused on the application of glycosidase …
Enzymatic transglycosylation for glycoconjugate synthesis
LX Wang, W Huang - Current opinion in chemical biology, 2009 - Elsevier
Remarkable advances have been made in recent years in exploiting the transglycosylation
activity of glycosidases and glycosynthase mutants for oligosaccharide and glycoconjugate …
activity of glycosidases and glycosynthase mutants for oligosaccharide and glycoconjugate …
Toward automated enzymatic synthesis of oligosaccharides
Oligosaccharides together with oligonucleotides and oligopeptides comprise the three major
classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide …
classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide …
Glycosynthase-catalysed syntheses at pH below neutrality
A Trincone, A Giordano, G Perugino, M Rossi… - Bioorganic & medicinal …, 2003 - Elsevier
The use of the new glycosynthase Ta-β-GlyE386G and of the already known Ss-β-GlyE387G
for the synthesis of interesting 4-methylumbelliferyl disaccharides and for the galactosylation …
for the synthesis of interesting 4-methylumbelliferyl disaccharides and for the galactosylation …
Controlled processivity in glycosyltransferases: A way to expand the enzymatic toolbox
Glycosyltransferases (GT) catalyse the biosynthesis of complex carbohydrates which are the
most abundant group of molecules in nature. They are involved in several key mechanisms …
most abundant group of molecules in nature. They are involved in several key mechanisms …
Use of O-glycosylation in total synthesis
H Pellissier - Tetrahedron, 2005 - Elsevier
Carbohydrates are the most abundant group of natural products and the role of sugars as
energy and biosynthetic resources (glycolysis, pentose phosphate cycle, etc.),'energy …
energy and biosynthetic resources (glycolysis, pentose phosphate cycle, etc.),'energy …
Metabolic substrate engineering as a tool for glycobiology
S Goon, CR Bertozzi - Journal of carbohydrate chemistry, 2002 - Taylor & Francis
The biological importance of oligosaccharides was first recognized in the context of their role
in metabolism and energy storage. During the past three decades, it has become apparent …
in metabolism and energy storage. During the past three decades, it has become apparent …
From glycoside hydrolases to thioglycoligases: the synthesis of thioglycosides
RV Stick, KA Stubbs - Tetrahedron: Asymmetry, 2005 - Elsevier
The treatment of various glycosyl acceptors, each containing a reactive thiol group, with the
appropriate glycosyl donor and a glycoside hydrolase or glycosynthase, failed to yield any …
appropriate glycosyl donor and a glycoside hydrolase or glycosynthase, failed to yield any …
Towards tailor-made oligosaccharides—chemo-enzymatic approaches by enzyme and substrate engineering
A Homann, J Seibel - Applied microbiology and biotechnology, 2009 - Springer
Carbohydrate structures have been identified in eukaryotic and prokaryotic cells as
glycoconjugates with communication skills. Their recently discussed role in various diseases …
glycoconjugates with communication skills. Their recently discussed role in various diseases …