On expanding the repertoire of glycosynthases: mutant β-galactosidases forming β-(1, 6)-linkages

DL Jakeman, SG Withers - Canadian journal of chemistry, 2002 - cdnsciencepub.com
Oligosaccharide synthesis by enzymatic processes offers the potential for thrusting
oligosaccharides to the forefront of pharmaceutical research, in part, due to expedient and …

Preparation of oligosaccharide units library and its utilization

T Murata, T Usui - Bioscience, biotechnology, and biochemistry, 1997 - academic.oup.com
There is high current interest in developing synthetic routes to oligosaccharides involved in
glycoconjugates. Significant attention has been focused on the application of glycosidase …

Enzymatic transglycosylation for glycoconjugate synthesis

LX Wang, W Huang - Current opinion in chemical biology, 2009 - Elsevier
Remarkable advances have been made in recent years in exploiting the transglycosylation
activity of glycosidases and glycosynthase mutants for oligosaccharide and glycoconjugate …

Toward automated enzymatic synthesis of oligosaccharides

L Wen, G Edmunds, C Gibbons, J Zhang… - Chemical …, 2018 - ACS Publications
Oligosaccharides together with oligonucleotides and oligopeptides comprise the three major
classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide …

Glycosynthase-catalysed syntheses at pH below neutrality

A Trincone, A Giordano, G Perugino, M Rossi… - Bioorganic & medicinal …, 2003 - Elsevier
The use of the new glycosynthase Ta-β-GlyE386G and of the already known Ss-β-GlyE387G
for the synthesis of interesting 4-methylumbelliferyl disaccharides and for the galactosylation …

Controlled processivity in glycosyltransferases: A way to expand the enzymatic toolbox

C Guidi, X Biarnés, A Planas, M De Mey - Biotechnology Advances, 2023 - Elsevier
Glycosyltransferases (GT) catalyse the biosynthesis of complex carbohydrates which are the
most abundant group of molecules in nature. They are involved in several key mechanisms …

Use of O-glycosylation in total synthesis

H Pellissier - Tetrahedron, 2005 - Elsevier
Carbohydrates are the most abundant group of natural products and the role of sugars as
energy and biosynthetic resources (glycolysis, pentose phosphate cycle, etc.),'energy …

Metabolic substrate engineering as a tool for glycobiology

S Goon, CR Bertozzi - Journal of carbohydrate chemistry, 2002 - Taylor & Francis
The biological importance of oligosaccharides was first recognized in the context of their role
in metabolism and energy storage. During the past three decades, it has become apparent …

From glycoside hydrolases to thioglycoligases: the synthesis of thioglycosides

RV Stick, KA Stubbs - Tetrahedron: Asymmetry, 2005 - Elsevier
The treatment of various glycosyl acceptors, each containing a reactive thiol group, with the
appropriate glycosyl donor and a glycoside hydrolase or glycosynthase, failed to yield any …

Towards tailor-made oligosaccharides—chemo-enzymatic approaches by enzyme and substrate engineering

A Homann, J Seibel - Applied microbiology and biotechnology, 2009 - Springer
Carbohydrate structures have been identified in eukaryotic and prokaryotic cells as
glycoconjugates with communication skills. Their recently discussed role in various diseases …