The pathogenesis of liver cell injury during chronic hepatitis C (CHC) is poorly understood.
The cellular immune response is thought to play a key role in both inhibition of viral …

CD8+ T cells represent a sizable component of the liver inflammatory infiltrate in chronic
hepatitis C and are thought to contribute to immune‐mediated tissue injury. Because chronic …

Background/Aims: The intrahepatic immune system is likely to play a key role in determining
the outcome of hepatitis C virus (HCV) infection. The hepatic lymphocyte repertoire is …

The aim was to assess the specificity and functional significance of liver‐infiltrating and
peripheral blood T cells in chronic hepatitis C. Peripheral blood mononuclear cells hepatitis …

Results Acute hepatitis patients had a high proportion of CD3+ T cells with increased CD4+
CD45RA-T helper and CD8+ CD11b-cytotoxic T cells. Compared to this group, chronic …

The immunopathological processes involved in hepatic damage during chronic hepatitis C
infection are not fully understood. Several works suggest the role of T helper 1 (Th1) immune …

This study was performed to compare the vigor and phenotype of virus-specific CD4+ and
CD8+ T-cell responses in patients with different virologic and clinical outcomes after …

Background/Aims: The role of cytotoxic T lymphocytes (CTL) in limiting viral replication and
producing hepatocellular injury in patients with chronic hepatitis C virus (HCV) infection is …

Abstract The CD4+ CD25+ regulatory T lymphocytes have been implicated in suppressing T
cell immune responses. Our aim was to characterize the frequency, phenotype, function, and …

BACKGROUND/AIMS: Hepatitis C virus (HCV) causes a chronic infection that can lead to
fibrosis and carcinoma. Immune responses mediated by cytotoxic T lymphocytes (CTLs) …