Background: To assess the role played by the immune response in the outcome of hepatitis
C virus infection, the CD4+ T-lymphocyte response to viral antigens was studied in infected …

CD8+ T lymphocytes play a major role in antiviral immune defense. Their significance for
acute hepatitis C is unclear. Our aim was to correlate the CD8+ T cell response with the …

HCV (hepatitis C virus) has a high propensity to persist and to cause chronic hepatitis C,
eventually leading to cirrhosis. Since HCV itself is not cytopathic, liver damage in chronic …

Recent studies using MHC class I tetramers have shown that CD8+ T cell responses against
different persistent viruses vary considerably in magnitude and phenotype. At one extreme …

Hepatitis C virus (HCV)-specific CD8+ T cells in peripheral blood mononuclear cells
(PBMCs) from patients infected with HCV were quantitatively analyzed by flow cytometry …

The pathogenic mechanism for hepatocellular damage in hepatitis C virus (HCV) infection
has not been clearly understood. Analysis of costimulatory molecules on lymphocytes may …

Summary CD4+ CD25+ T regulatory cells may play a role in the different clinical
presentations of chronic hepatitis C virus (HCV) infection by suppressing CD4+ T cell …

The adult liver is an organ without constitutive lymphoid components. Therefore, any
intrahepatic T cell found in chronic hepatitis should have migrated to the liver after infection …

CD56+ T cells are abundant in liver and play an important role in defense against viral
infections. However, the role of CD56+ T cells in control of hepatitis C virus (HCV) infection …

Hepatitis C virus (HCV) replicates in immune cells in both chronic hepatitis C (CHC) and
occult HCV infection, but the extent of virus replication in this compartment in these opposing …