WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Despite the clinical use of piperacillin
for more than two decades, there are still contradictory reports whether or not the elimination …

Piperacillin in combination with tazobactam is one of the most commonly used intravenous
antibiotics. There is evidence for a possible saturable elimination of piperacillin. Therefore …

Dosing recommendations for continuous infusion of piperacillin, a broad-spectrum beta-
lactam antibiotic, are mainly guided by outputs from population pharmacokinetic models …

The pharmacokinetics of a single 4 g intravenous bolus dose of piperacillin were
investigated in 5 normal subjects and 13 patients with moderate, severe or end-stage renal …

Objectives Piperacillin is a β-lactam antimicrobial frequently used in critically ill patients with
acute kidney injury treated with continuous renal replacement therapy (CRRT). However …

The pharmacokinetics of piperacillin were examined after single intravenous doses to three
groups of male patients with creatinine clearances of greater than or equal to 60 (group I) …

Piperacillin was administered to normal, healthy volunteers by an intravenous infusion over
30 min at dosage regimens of 12 gm daily (4 gm every 8 hr) and 24 gm daily (6 gm every 6 …

The pharmacokinetic parameters of piperacillin sodium were studied in eight volunteer
subjects with chronic renal failure. Subjects were given a single 30-min intravenous infusion …

The objectives of this study were (i) to compare the plasma concentration–time profiles for
first-dose and steady-state piperacillin administered by intermittent or continuous dosing to …

The study aimed to evaluate saturation of piperacillin elimination in critically ill adult patients.
Seventeen critically ill adult patients received continuous and intermittent infusion of …