The aim of this study was to elucidate the molecular basis for viral clearance and liver
disease in the pathogenesis of hepatitis B virus (HBV) infection. Using transgenic mice that …

Hepatitis B virus (HBV) is a noncytopathic virus that causes liver disease of variable duration
and severity. It is widely assumed that during HBV infection the host immune response is …

It is widely believed that viral clearance is mediated principally by the destruction of infected
cells by CTLs. In this report, we use a transgenic mouse model of HBV replication to …

During hepatitis B virus (HBV) infection, distinct host-virus interactions may establish the
patterns of viral clearance and persistence and the extent of virus-associated pathology. It is …

The adaptive immune response is thought to be responsible for viral clearance and disease
pathogenesis during hepatitis B virus infection. It is generally acknowledged that the …

Hepatitis B virus (HBV) infection has a low rate of chronicity compared to HCV infection, but
chronic liver inflammation can evolve to life threatening complications. Experimental data …

Hepatitis B virus (HBV) is a non-cytopathic, hepatotropic virus with the potential to cause a
persistent infection, ultimately leading to cirrhosis and hepatocellular carcinoma. Over the …

It is generally thought that viral clearance is mediated primarily by antigen-specific T cell
responses that destroy infected cells. This assumption may not be true for all viruses. Recent …

To understand the role of cytotoxic T cells in liver damage and viral control, we used human
histocompatibility leukocyte antigen (HLA)-peptide tetramers that allow direct ex vivo …

Resolution of hepatitis B virus (HBV) infection was believed to be attributed to the cytotoxic T
cell–mediated killing of infected hepatocytes. However, studies in HBV transgenic mice and …