Naturally-occurring alkaloids of plant origin as potential antimicrobials against antibiotic-resistant infections

B Casciaro, L Mangiardi, F Cappiello, I Romeo… - Molecules, 2020 - mdpi.com
Antibiotic resistance is now considered a worldwide problem that puts public health at risk.
The onset of bacterial strains resistant to conventional antibiotics and the scarcity of new …

Research progress on antibacterial activities and mechanisms of natural alkaloids: A review

Y Yan, X Li, C Zhang, L Lv, B Gao, M Li - Antibiotics, 2021 - mdpi.com
Alkaloids are nitrogen-containing heterocyclic compounds typically isolated from plants.
They represent one of the most important types of natural products because of their large …

Antimicrobial activity of polyphenols and alkaloids in middle eastern plants

L Othman, A Sleiman, RM Abdel-Massih - Frontiers in microbiology, 2019 - frontiersin.org
Antibiotic-resistant microorganisms have been an ever-growing concern over the past years.
This has led researchers to direct their attention onto plants to be able to discover new …

The biological activity of natural alkaloids against herbivores, cancerous cells and pathogens

A Thawabteh, S Juma, M Bader, D Karaman, L Scrano… - Toxins, 2019 - mdpi.com
The growing incidence of microorganisms that resist antimicrobials is a constant concern for
the scientific community, while the development of new antimicrobials from new chemical …

Antifungal potential of alkaloids as an emerging therapeutic target

H Khan, MS Mubarak, S Amin - Current drug targets, 2017 - ingentaconnect.com
Background: Fungal infections have been causing serious problems in all age groups,
especially in immune-compromised individuals. Various synthetic agents are in clinical …

Antibacterial and antifungal alkaloids from Asian angiosperms: Distribution, mechanisms of action, structure-activity, and clinical potentials

M Sulaiman, K Jannat, V Nissapatorn, M Rahmatullah… - Antibiotics, 2022 - mdpi.com
The emergence of multidrug-resistant bacteria and fungi requires the development of
antibiotics and antifungal agents. This review identified natural products isolated from Asian …

Antibacterial properties of medicinal plants: recent trends, progress, and challenges

L Abate, A Bachheti, RK Bachheti… - Traditional herbal therapy …, 2021 - taylorfrancis.com
Resistance in microbes towards existing antibiotics has become a part of natural adaptation,
leading to the survival of resistant microbial strains. It can be attributed to the extreme and …

Review on plant antimicrobials: a mechanistic viewpoint

B Khameneh, M Iranshahy, V Soheili… - … Resistance & Infection …, 2019 - Springer
Microbial resistance to classical antibiotics and its rapid progression have raised serious
concern in the treatment of infectious diseases. Recently, many studies have been directed …

Secondary plant metabolites as potent drug candidates against antimicrobial-resistant pathogens

K Keita, C Darkoh, F Okafor - SN Applied Sciences, 2022 - Springer
Antibiotic resistance is a major public health threat of the twenty-first century and represents
an important risk to the global economy. Healthcare-associated infections mainly caused by …

Tackling antibiotic resistance with compounds of natural origin: A comprehensive review

FJ Álvarez-Martínez, E Barrajón-Catalán, V Micol - Biomedicines, 2020 - mdpi.com
Drug-resistant bacteria pose a serious threat to human health worldwide. Current antibiotics
are losing efficacy and new antimicrobial agents are urgently needed. Living organisms are …