Methods The BSA solution (0.1 mM) was prepared daily in Tris buffer (0.05 mol l-1, pH= 7.4)
and treated at final concentration of 1.67× 10-5 M with different amounts of erlotinib …

The interaction between erlotinib and human serum albumin (HSA) in simulated
physiological conditions was investigated by spectroscopic methods. The results revealed …

Bovine serum albumin (BSA) is the most abundant protein in the blood circulation and it is
commonly used for drug delivery in blood. Therefore, we aim to study BSA interaction with …

Human serum albumin (HSA) is a globular and monomeric protein in plasma that transports
many drugs and compounds. Binding of some drugs to HSA can lead to changes in its …

The purpose of this study was to investigate the site-selective binding of erlotinib
hydrochloride (ET), a targeted anticancer drug, to bovine serum albumin (BSA) through 1H …

Flavonoid-containing food supplements are widely used as antioxidants, and the continuous
use of these supplements with other drugs can lead to clinically significant interactions …

The affinity of a drug to serum albumin has influence on the pharmacokinetics of a drug. In
the present study, the mutual interaction of metformin hydrochloride (MET) with bovine …

The interaction between erlotinib (ERL) and bovine serum albumin (BSA) was studied in the
presence of quercetin (QUR), a flavonoid with antioxidant properties. Ligands bind to the …

Binding interactions between human serum albumin (HSA) and four approved epidermal
growth factor receptor (EGFR) inhibitors gefitinib (GEF), erlotinib (ERL), afatinib (AFA) …

The interaction of afatinib (AFB) with bovine serum albumin (BSA) was examined via
fluorescence and UV-Vis spectroscopy. Spectrofluorimetric measurements revealed that …