Significant variability in response to inhaled corticosteroids for persistent asthma

SJ Szefler, RJ Martin, TS King, HA Boushey… - Journal of Allergy and …, 2002 - Elsevier
Background: A clinical model is needed to compare inhaled corticosteroids (ICSs) with
respect to efficacy. Objective: The purpose of this investigation was to compare the relative …

Safety of the newer inhaled corticosteroids in childhood asthma

TL Randell, KC Donaghue, GR Ambler, CT Cowell… - Pediatric Drugs, 2003 - Springer
Inhaled corticosteroids (ICS) remain a vital part of the management of persistent asthma, but
concerns have been raised about their potential adverse effects in children. This review …

Update on National Asthma Education and Prevention Program pediatric asthma treatment recommendations

NS Eid - Clinical pediatrics, 2004 - journals.sagepub.com
The National Asthma Education and Prevention Program (NAEPP) published an update on
selected topics from the 1997 Guidelines for the Diagnosis and Management of Asthma and …

Daily versus as-needed corticosteroids for mild persistent asthma

HA Boushey, CA Sorkness, TS King… - … England Journal of …, 2005 - Mass Medical Soc
Background Although guidelines recommend daily therapy for patients with mild persistent
asthma, prescription patterns suggest that most such patients use these so-called controller …

Effects of glucocorticoids on the hypothalamic-pituitary-adrenal axis in children and adults

T Gulliver, N Eid - Immunology and Allergy Clinics, 2005 - immunology.theclinics.com
The severe adverse effects of chronic oral corticosteroids, including suppression of the
hypothalamo-pituitary-adrenal (HPA) axis, growth failure, and delays in skeletal maturation …

Safety of high-dose inhaled corticosteroids

NC Barnes - Respiratory medicine, 1993 - Elsevier
Inhaled corticosteroids are being given to more patients, at increasing doses and for longer
periods of time. This has led to renewed concern about side-effects, particularly when higher …

Efficacy and safety of inhaled corticosteroids: new developments

PJ Barnes, S Pedersen, WW Busse - American journal of respiratory …, 1998 - atsjournals.org
Inhaled corticosteroids have revolutionized the treatment of asthma and have now become
the mainstay of therapy for patients with chronic disease (1). In a supplement to this journal …

Pharmaceutical characteristics that influence the clinical efficacy of inhaled corticosteroids

HW Kelly - Annals of Allergy, Asthma & Immunology, 2003 - Elsevier
BACKGROUND: Inhaled corticosteroids (ICSs) are the most effective therapy for the
management of persistent asthma. The aim of ICS therapy is to achieve a high anti …

Patterns of inhaled corticosteroid use and asthma control in the Childhood Asthma Management Program Continuation Study

GS Sawicki, RC Strunk, B Schuemann, R Annett… - Annals of Allergy …, 2010 - Elsevier
BACKGROUND: Daily controller medication use is recommended for children with persistent
asthma to achieve asthma control. OBJECTIVE: To examine patterns of inhaled …

Long-term safety of once-daily budesonide in patients with early-onset mild persistent asthma: results of the Inhaled Steroid Treatment as Regular Therapy in Early …

AL Sheffer, M Silverman, AJ Woolcock, PV Díaz… - Annals of Allergy …, 2005 - Elsevier
BACKGROUND: The Inhaled Steroid Treatment as Regular Therapy in Early Asthma
(START) study is a worldwide, randomized, prospective study to investigate early …