The purpose of this study was to determine whether chronic exercise alters sensitivity to the
conditioned rewarding effects of cocaine. Female rats were obtained at weaning and …

Background The potential of abused drugs to induce addiction and compulsive drug-related
behavior is associated with their ability to alter dopamine signaling. Dopamine plays a key …

It is thought that rewarding experiences with drugs create strong contextual associations and
encourage repeated intake. In turn, repeated exposures to drugs of abuse make lasting …

The conditioned place preference paradigm was used to investigate the reinforcing
properties of cocaine. Rats were injected (ip) with cocaine hydrochloride (0.625–20 mg/kg) …

Rationale Acute cocaine administration produces an initial rewarding state followed by a
dysphoric/anxiogenic “crash.” Objective The objective of this study was to determine whether …

Cocaine reward was demonstrated by establishing a conditioned place preference (CPP) to
a distinctive location paired with cocaine administered either intravenously (iv, 0.5 mg/kg) or …

Only a subgroup of human drug users progress from initial drug taking to drug addiction. The
learned associations between the effects of the drug and the environment in which it is …

Rationale and objectives Drug-seeking behavior occurs more readily in some individuals
than others. This phenomenon is considered in studies of drug self-administration in which …

The paradigm of conditioned place preference has been widely used to demonstrate the
rewarding properties of psychomotor stimulants. Such drugs also stimulate locomotor …

Human cocaine users report that the initial “high” produced by cocaine administration is
followed by an anxiogenic “crash”. Given that cocaine has such robust and opposing …