Metabolic partitioning in the brain and its hijacking by glioblastoma
J de Ruiter Swain, E Michalopoulou… - Genes & …, 2023 - genesdev.cshlp.org
The different cell types in the brain have highly specialized roles with unique metabolic
requirements. Normal brain function requires the coordinated partitioning of metabolic …
requirements. Normal brain function requires the coordinated partitioning of metabolic …
Emerging approaches for targeting metabolic vulnerabilities in malignant glioma
PM Clark, WX Mai, TF Cloughesy… - Current neurology and …, 2016 - Springer
Malignant gliomas are intractable and among the most lethal human malignancies. Like
other cancers, metabolic reprogramming is a key feature of glioma and is thought to …
other cancers, metabolic reprogramming is a key feature of glioma and is thought to …
[HTML][HTML] Metabolic remodeling in glioma immune microenvironment: intercellular interactions distinct from peripheral tumors
R Qiu, Y Zhong, Q Li, Y Li, H Fan - Frontiers in cell and …, 2021 - frontiersin.org
During metabolic reprogramming, glioma cells and their initiating cells efficiently utilized
carbohydrates, lipids and amino acids in the hypoxic lesions, which not only ensured …
carbohydrates, lipids and amino acids in the hypoxic lesions, which not only ensured …
[HTML][HTML] Metabolic drivers of invasion in glioblastoma
Glioblastoma is a primary malignant brain tumor with a median survival under 2 years. The
poor prognosis glioblastoma caries is largely due to cellular invasion, which enables escape …
poor prognosis glioblastoma caries is largely due to cellular invasion, which enables escape …
The interplay between metabolic remodeling and immune regulation in glioblastoma
P Kesarwani, S Kant, A Prabhu, P Chinnaiyan - Neuro-oncology, 2017 - academic.oup.com
The fields of tumor metabolism and immune oncology have both independently received
considerable attention over the last several years. The majority of research in tumor …
considerable attention over the last several years. The majority of research in tumor …
[HTML][HTML] Altered metabolism in glioblastoma: Myeloid-derived suppressor cell (MDSC) fitness and tumor-infiltrating lymphocyte (TIL) dysfunction
N Di Ianni, S Musio, S Pellegatta - International journal of molecular …, 2021 - mdpi.com
The metabolism of glioblastoma (GBM), the most aggressive and lethal primary brain tumor,
is flexible and adaptable to different adverse conditions, such as nutrient deprivation …
is flexible and adaptable to different adverse conditions, such as nutrient deprivation …
Metabolic heterogeneity and adaptability in brain tumors
The metabolic complexity and flexibility commonly observed in brain tumors, especially
glioblastoma, is fundamental for their development and progression. The ability of tumor …
glioblastoma, is fundamental for their development and progression. The ability of tumor …
Metabolic remodeling contributes towards an immune-suppressive phenotype in glioblastoma
P Kesarwani, A Prabhu, S Kant… - Cancer Immunology …, 2019 - Springer
Glioblastoma (GBM) is one of the most aggressive tumors. Numerous studies in the field of
immunotherapy have focused their efforts on identifying various pathways linked with tumor …
immunotherapy have focused their efforts on identifying various pathways linked with tumor …
[HTML][HTML] Targeting immunometabolism in glioblastoma
AA Mohan, WH Tomaszewski… - Frontiers in …, 2021 - frontiersin.org
We have only recently begun to understand how cancer metabolism affects antitumor
responses and immunotherapy outcomes. Certain immunometabolic targets have been …
responses and immunotherapy outcomes. Certain immunometabolic targets have been …
Altered cellular metabolism in gliomas—An emerging landscape of actionable co-dependency targets
Altered cellular metabolism is a hallmark of gliomas. Propelled by a set of recent
technological advances, new insights into the molecular mechanisms underlying glioma …
technological advances, new insights into the molecular mechanisms underlying glioma …