A sequential transaxonal disease spread of amyotrophic lateral sclerosis (ALS)-associated
TDP-43 pathology in four stages has been defined by post-mortem data, which have been …

Background After the demonstration of a corticoefferent propagation pattern in amyotrophic
lateral sclerosis (ALS) by neuropathological studies, this concept has been used for in vivo …

Background There is an ongoing debate whether primary lateral sclerosis (PLS) should be
regarded as an independent disease entity separate from amyotrophic lateral sclerosis …

Amyotrophic lateral sclerosis is a progressive neurodegenerative disease that affects upper
and lower motor neurons. Observational and intervention studies can be tracked using …

Aims To investigate microstructural impairments of corticospinal tracts (CSTs) with different
origins in amyotrophic lateral sclerosis (ALS) using neurite orientation dispersion and …

Objective: The potential of magnetic resonance imaging (MRI) as a technical biomarker for
cerebral microstructural alterations in neurodegenerative diseases is under investigation. In …

BACKGROUND: MR diffusion tensor imaging (DTI) appears to be a powerful method to
investigate the neuronal and axonal fibre distribution in the human brain. Changes in …

Whether longitudinal diffusion tensor MRI imaging (DTI) can capture disease progression in
patients with amyotrophic lateral sclerosis (ALS) is unclear. The primary goal of this study …

Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder,
caused by progressive loss of motor neurons. Changes are widespread in the subcortical …

Background The results of recent diffusion tensor imaging (DTI) studies on amyotrophic
lateral sclerosis (ALS) are inconclusive and controversial. We performed a voxel-based …