Is neuroimmunomodulation a future therapeutic approach for sepsis?
Sepsis is considered as a disease of profoundly and uncontrollably activated innate immune
response against bacterial infection or their products. Thus, regulation of innate immune …
response against bacterial infection or their products. Thus, regulation of innate immune …
Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis
A Kanashiro, F Sônego, RG Ferreira… - Pharmacological …, 2017 - Elsevier
Sepsis is one of the main causes of mortality in hospitalized patients. Despite the recent
technical advances and the development of novel generation of antibiotics, severe sepsis …
technical advances and the development of novel generation of antibiotics, severe sepsis …
[HTML][HTML] Neural reflex regulation of systemic inflammation: potential new targets for sepsis therapy
R Fernandez, G Nardocci, C Navarro, EP Reyes… - Frontiers in …, 2014 - frontiersin.org
Sepsis progresses to multiple organ dysfunction due to the uncontrolled release of
inflammatory mediators, and a growing body of evidence shows that neural signals play a …
inflammatory mediators, and a growing body of evidence shows that neural signals play a …
[HTML][HTML] Neuroimmune perspectives in sepsis
L Ulloa, EA Deitch - Critical Care, 2009 - Springer
Physiologic anti-inflammatory mechanisms are selected by evolution to control the immune
system and to prevent infectious and inflammatory disorders. Central-acting α 2-agonists …
system and to prevent infectious and inflammatory disorders. Central-acting α 2-agonists …
Cholinergic regulatory lymphocytes re-establish neuromodulation of innate immune responses in sepsis
G Peña, B Cai, L Ramos, G Vida… - The Journal of …, 2011 - journals.aai.org
Many anti-inflammatory strategies that are successful in treating sepsis in healthy animals
fail in clinical trials, in part because sepsis normally involves immunocompromised patients …
fail in clinical trials, in part because sepsis normally involves immunocompromised patients …
Vagal modulation of the inflammatory response in sepsis
DW Wang, YM Yin, YM Yao - International reviews of immunology, 2016 - Taylor & Francis
The vagus nerve can sense peripheral inflammation and transmit action potentials from the
periphery to the brainstem. Vagal afferent signaling is integrated in the brainstem, and …
periphery to the brainstem. Vagal afferent signaling is integrated in the brainstem, and …
Inflammatory mediators of cytokines and chemokines in sepsis: From bench to bedside
Background: Sepsis is a serious clinical condition characterized by damage to the immune
system as a result of an uncontrolled response to infection. Septic patients show …
system as a result of an uncontrolled response to infection. Septic patients show …
[PDF][PDF] Sympathetic excitotoxicity in sepsis: pro-inflammatory priming of macrophages by norepinephrine
[Frontiers in Bioscience 10, 2217-2229, September 1, 2005] 2217 SYMPATHETIC
EXCITOTOXICITY IN SEPSIS: PRO-INFLAMMATORY PRIMING O Page 1 [Frontiers in …
EXCITOTOXICITY IN SEPSIS: PRO-INFLAMMATORY PRIMING O Page 1 [Frontiers in …
Immunomodulatory therapy for sepsis: an update
E Christaki, P Anyfanti, SM Opal - Expert review of anti-infective …, 2011 - Taylor & Francis
Currently the treatment mainstay of sepsis is early and appropriate antibiotic therapy,
accompanied by aggressive fluid administration, the use of vasopressors when needed and …
accompanied by aggressive fluid administration, the use of vasopressors when needed and …
Mechanisms of brain signaling during sepsis
N Akrout, T Sharshar, D Annane - Current neuropharmacology, 2009 - ingentaconnect.com
Brain signaling is a crucial event for the body to mount an appropriate response to invading
microorganisms. Pro-inflammatory cytokines are released from infected tissues and reach …
microorganisms. Pro-inflammatory cytokines are released from infected tissues and reach …