Therapy for severe sepsis and septic shock remains a major unmet medical need and novel
treatments to regulate the disordered inflammatory response in sepsis are needed if …

Clinical and experimental studies with LPS injection have shown an increase in vasopressin
(AVP) secretion in the early phase of severe sepsis, which is subsequently reduced despite …

Sepsis is a life-threatening medical condition that occurs when the host has an uncontrolled
or abnormal immune response to overwhelming infection. It is now widely accepted that …

Each of these homeostatic systems is complex and more so, the interactions between them.
Currently, there is abundant work that confirms this bidirectional communication, which …

Sepsis, a clinical syndrome occurring in patients following infection or injury, is a leading
cause of morbidity and mortality worldwide. Current immunological mechanisms do not …

Background: Sepsis is a clinical condition due to an infectious event which leads to an early
hyper-inflammatory phase followed by a status of tolerance or immune paralysis. Hyper …

An exceptionally high mortality rate is observed in sepsis and septic shock. Systemic
administration of lipopolysaccharide (LPS) has been used as an experimental model for …

Sepsis is a syndrome characterized by systemic inflammatory responses to a severe
infection. Acute hyper-inflammatory reactions in the acute phase of sepsis have been …

Sepsis is defined as severe systemic inflammation in response to invading pathogens, or an
uncontrolled hyperinflammatory response, as mediated by the release of various …

Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host
responses to infection. Not only does sepsis pose a serious hazard to human health, but it …