Aims: Although preeclampsia (PE) has been attributed to excessive oxidative stress (OS) in
the placenta, mild antioxidants failed to prevent PE in clinical trials. As mitochondria are a …

Aberrant placentation generating placental oxidative stress is proposed to play a critical role
in the pathophysiology of preeclampsia. Unfortunately, therapeutic trials of antioxidants have …

Introduction Impaired utero-placental perfusion is a well-known feature of early
preeclampsia and is associated with placental hypoxia and oxidative stress. Although …

Hypoxia is a common and severe stress to an organism's homeostatic mechanisms, and
hypoxia during gestation is associated with significantly increased incidence of maternal …

Human pregnancy can be affected by numerous pathologies, from those which are mild and
reversible to others which are life-threatening. Among these, gestational diabetes mellitus …

Preeclampsia is a devastating pregnancy disorder. Severity varies widely, and while severe
preeclampsia often requires pre-term delivery, women with mild preeclampsia may reach …

Background Oxidative stress in preeclampsia and small for gestational age (SGA) birth
suggests antioxidant supplementation could prevent these conditions. However, it remains …

Pre-eclampsia is a disorder characterised by pregnancy-induced hypertension and new-
onset proteinuria occurring in the second half of pregnancy. Worldwide, approximately 2 …

Placental oxidative stress plays a key role in the pathophysiology of placenta-related
disorders, most notably preeclampsia (PE) and intrauterine growth restriction (IUGR) …

Preeclampsia (PE) is a multisystem disorder that remains a major cause of maternal and
foetal morbidity and death. To date, no treatment has been found that prevents the …