Dendrimers as potential drug carriers; encapsulation of acidic hydrophobes within water soluble PAMAM derivatives

AE Beezer, ASH King, IK Martin, JC Mitchel… - Tetrahedron, 2003 - Elsevier
This paper describes the synthesis of three neutral water soluble poly
(amidoamine)(PAMAM) dendrimer derivatives. The ability of the two larger dendrimers to …

The synthesis of water soluble dendrimers, and their application as possible drug delivery systems

LJ Twyman, AE Beezer, R Esfand, MJ Hardy… - Tetrahedron …, 1999 - Elsevier
The synthesis of two water soluble dendrimers is described. The formation of water soluble
inclusion complexes with a variety of small, hydrophobic guest molecules is also described …

Effect of solvent and pH on the structure of PAMAM dendrimers

PK Maiti, T Çaǧın, ST Lin, WA Goddard - Macromolecules, 2005 - ACS Publications
We report various structural and conformational properties of generations 4, 5, and 6
PAMAM (polyamidoamine) dendrimer [EDA (ethylenediamine) core)] at various protonation …

Poly (amidoamine) dendrimers as a pharmaceutical excipient. Are we there yet?

DP Otto, MM De Villiers - Journal of pharmaceutical sciences, 2018 - Elsevier
Drug solubility could affect the therapeutic use of a drug because the biological activity of a
drug is only possible if some fraction of a dissolved drug can permeate and overcome …

[HTML][HTML] Dendrimers for drug delivery

AS Chauhan - Molecules, 2018 - mdpi.com
Dendrimers have come a long way in the last 25 years since their inception. Originally
created as a wonder molecule of chemistry, dendrimer is now in the fourth class of polymers …

PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy

F Abedi-Gaballu, G Dehghan, M Ghaffari, R Yekta… - Applied materials …, 2018 - Elsevier
Drug delivery systems for cancer chemotherapy are employed to improve the effectiveness
and decrease the side-effects of highly toxic drugs. Most chemotherapy agents have …

Polycationic (mixed) core–shell dendrimers for binding and delivery of inorganic/organic substrates

AW Kleij, R van de Coevering… - … A European Journal, 2001 - Wiley Online Library
The convergent synthesis of a series of polycationic aryl ether dendrimers has been
accomplished by a convenient procedure involving quantitative quaternarization of aryl …

Hydrophobically modified poly (amidoamine)(PAMAM) dendrimers: their properties at the air–water interface and use as nanoscopic container molecules

Y Sayed-Sweet, DM Hedstrand, R Spinder… - Journal of Materials …, 1997 - pubs.rsc.org
Tri-and tetra-dendron poly (amidoamine)(PAMAM) dendrimers were converted into
hydrocarbon-soluble polymers and used as hydrophobic nanoscopic scaffolding by reacting …

Dendrimers as drug delivery vehicles: non‐covalent interactions of bioactive compounds with dendrimers

HL Crampton, EE Simanek - Polymer international, 2007 - Wiley Online Library
This mini review highlights issues associated with the use of dendrimers as drug delivery
vehicles. The review introduces dendrimers and summarizes findings on their use in vivo …

Poly (amidoamine)(PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications

R Esfand, DA Tomalia - Drug discovery today, 2001 - Elsevier
Poly (amidoamine)(PAMAM) dendrimers are the first complete dendrimer family to be
synthesized, characterized and commercialized. Based on this extensive activity, they are …