Background There is increasing evidence of a constitutive activation of Akt in pancreatic
ductal adenocarcinoma (PDAC), associated with poor prognosis and chemoresistance …

Purpose: Akt is a serine/threonine kinase that plays a central role in tumorigenesis. Among
the members of Akt family, Akt2 is associated with the development of human cancers. The …

The PI3K/Akt signaling pathway is constitutively activated in some pancreatic cancers; when
activated, it inhibits chemotherapy-mediated apoptosis. We examined whether Akt activity …

The phosphoinositide 3 kinase AKT mammalian target of rapamycin (PI3K-AKTmTOR)
signaling pathway is an important in the aetiology of pancreatic cancer (PC) and is …

Invasion, metastasis and resistance to conventional chemotherapeutic agents are obstacles
to successful treatment of pancreatic cancer, and a better understanding of the molecular …

Despite advances in molecular pathogenesis, pancreatic cancer remains a major unsolved
health problem. It is a rapidly invasive, metastatic tumor that is resistant to standard …

There is currently no effective treatment for pancreatic ductal adenocarcinoma (PDAC).
While palliative chemotherapy offers a survival benefit to most patients, nearly all will …

Pancreatic-ductal-adenocarcinoma (PDAC) is amongst the most lethal malignancies, mainly
because of its metastatic spread and multifactorial chemoresistance. Since c-Met is a marker …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly cancers worldwide.
Although many regimens have been used for PDAC treatment, the combination of the EGF …

The aberrant activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)
pathway is common in pancreatic ductal adenocarcinomas (PDAC). The application of …