In mammalian development, epigenetic modifications, including DNA methylation patterns,
play a crucial role in defining cell fate but also represent epigenetic barriers that restrict …

Background DNA methylation in mammals is an epigenetic mark necessary for normal
embryogenesis. During development active loss of methylation occurs in the male …

Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …

DNA methylation is dynamically remodelled during the mammalian life cycle through distinct
phases of reprogramming and de novo methylation. These events enable the acquisition of …

The molecular pathways that regulate gain and loss of DNA methylation during mammalian
development need to be tightly balanced to maintain a physiological equilibrium. Here we …

Epigenetic reprogramming involves processes that lead to the erasure of epigenetic
information, reverting the chromatin template to a less differentiated state. Extensive …

DNA methylation is a fundamentally important epigenetic modification of the mammalian
genome that has widespread influences on gene expression. During germ-cell specification …

In mouse and most other mammalian species, the paternal and maternal genomes undergo
parent-specific epigenetic reprogramming during preimplantation development. The …

DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …

DNA methylation is a carrier of important regulatory information that undergoes global
reprogramming in the mammalian germ line, including pre-implantation embryos and …