Key points• There is disagreement about whether muscle hypertrophy requires the activation
and fusion of satellite cells, the quiescent muscle stem cells, to the multinucleated post …

Myostatin, a member of the TGF-β family, has been identified as a powerful inhibitor of
muscle growth. Absence or blockade of myostatin induces massive skeletal muscle …

Sarcopenia is a progressive age‐related loss of skeletal muscle mass and strength.
Parabiotic experiments show that circulating factors positively influence the proliferation and …

Myostatin and activin A are structurally related secreted proteins that act to limit skeletal
muscle growth. The cellular targets for myostatin and activin A in muscle and the role of …

Satellite cells are quiescent muscle stem cells that promote postnatal muscle growth and
repair. Here we show that myostatin, a TGF-β member, signals satellite cell quiescence and …

Muscular dystrophies comprise a large group of inherited disorders that lead to progressive
muscle wasting. We wanted to investigate if targeting satellite cells can enhance muscle …

Skeletal muscle regeneration and work-induced hypertrophy rely on molecular events
responsible for activation and quiescence of resident myogenic stem cells, satellite cells …

Muscle mass is decreased with advancing age, likely due to altered regulation of muscle
fiber size. This study was designed to investigate cellular mechanisms contributing to this …

Satellite cells from adult rat muscle coexpress proliferating cell nuclear antigen and MyoD
upon entry into the cell cycle, suggesting that MyoD plays a role during the recruitment of …

Abstract Changes in muscle mass may result from changes in protein turnover, reflecting the
balance between protein synthesis and protein degradation, and changes in cell turnover …