[HTML][HTML] Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence
D Mischoulon, M Fava - The American journal of clinical nutrition, 2002 - Elsevier
Major depression remains difficult to treat, despite the wide array of registered
antidepressants available. In recent years there has been a surge in the popularity of natural …
antidepressants available. In recent years there has been a surge in the popularity of natural …
S-adenosyl-methionine in depression: a comprehensive review of the literature
GI Papakostas, JE Alpert, M Fava - Current psychiatry reports, 2003 - Springer
Abstract As many as 29% to 46% of patients with major depressive disorder (MDD) show
only partial or no response to an adequate course of an antidepressant. The current practice …
only partial or no response to an adequate course of an antidepressant. The current practice …
[HTML][HTML] Evidence for S-adenosyl-L-methionine (SAM-e) for the treatment of major depressive disorder
GI Papakostas - The Journal of clinical psychiatry, 2009 - psychiatrist.com
Despite the increasingly large array of antidepressants available to treat major depressive
disorder, patients continue to experience relatively modest response and remission rates. In …
disorder, patients continue to experience relatively modest response and remission rates. In …
Efficacy and tolerability of oral and intramuscular S-adenosyl-L-methionine 1, 4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with …
R Delle Chiaie, P Pancheri, P Scapicchio - The American journal of clinical …, 2002 - Elsevier
ABSTRACT Background: S-Adenosyl-l-methionine (SAMe), a natural compound, is the most
important methyl donor in the central nervous system. In several clinical trials, SAMe showed …
important methyl donor in the central nervous system. In several clinical trials, SAMe showed …
S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research
A Sharma, P Gerbarg, T Bottiglieri… - The Journal of clinical …, 2017 - psychiatrist.com
Objective: A systematic review on S-adenosylmethionine (SAMe) for treatment of
neuropsychiatric conditions and comorbid medical conditions. Data Sources: Searches were …
neuropsychiatric conditions and comorbid medical conditions. Data Sources: Searches were …
A comprehensive review on the efficacy of S-Adenosyl-L-methionine in Major Depressive Disorder.
Objective. To review the antidepressant efficacy of S-Adenosyl-L-Methionine (SAMe) both in
monotherapy and/or in augmentation with antidepressants to better understand its potential …
monotherapy and/or in augmentation with antidepressants to better understand its potential …
The antidepressant potential of oral S‐adenosyl‐l‐methionine
JF Rosenbaum, M Fava, WE Falk… - Acta Psychiatrica …, 1990 - Wiley Online Library
S‐adenosyl‐l‐methionine (SAMe), a naturally occurring brain metabolite, has previously
been found to be effective and tolerated well in parenteral form as a treatment of major …
been found to be effective and tolerated well in parenteral form as a treatment of major …
[HTML][HTML] S-Adenosylmethionine (SAMe) in major depressive disorder (MDD): a clinician-oriented systematic review
A Cuomo, B Beccarini Crescenzi, S Bolognesi… - Annals of general …, 2020 - Springer
Background Major depressive disorder (MDD) is a recurrent illness with high rates of
chronicity, treatment-resistance, and significant economic impact. S-Adenosylmethionine …
chronicity, treatment-resistance, and significant economic impact. S-Adenosylmethionine …
Oral S-adenosyl-L-methionine in depression
M De Vanna, R Rigamonti - Current therapeutic research, 1992 - Elsevier
The antidepressant activity of oral S-adenosyl-L-methionine (SAMe) was evaluated in a
randomized, double-blind, imipramine-controlled trial in 30 patients with major depression …
randomized, double-blind, imipramine-controlled trial in 30 patients with major depression …
S‐adenosyl‐l‐methionine (SAMe) as antidepressant: meta‐analysis of clinical studies
GM Bressa - Acta Neurologica Scandinavica, 1994 - Wiley Online Library
Introduction‐S‐adenosyl‐l‐methionine (SAMe) is a naturally‐occurring substance which is a
major source of methyl groups in the brain. Material and methods‐We conducted a meta …
major source of methyl groups in the brain. Material and methods‐We conducted a meta …