Cells Stimulated with More Than One Toll-Like Receptor–Ligand in the Presence of a MyD88 Inhibitor Augmented Interferon-β via MyD88-Independent Signaling …
KU Saikh, CM Ranji - Viral Immunology, 2021 - liebertpub.com
Host exposure to pathogens engage multiple pathogen recognition receptors (PRRs)
including toll-like receptors (TLRs); recruit intracellular signaling adaptor proteins primarily …
including toll-like receptors (TLRs); recruit intracellular signaling adaptor proteins primarily …
Protective role of surface Toll-like receptor 9 expressing neutrophils in local inflammation during systemic inflammatory response syndrome in mice
X Meng, W Sun, Y Ren, Y Xiao, P Zhao, W Lu… - Molecular …, 2017 - Elsevier
Clinically, systemic inflammatory response syndrome (SIRS) occurs after serious trauma or
sepsis. In sepsis, neutrophils are the major effector cells responsible for eliminating …
sepsis. In sepsis, neutrophils are the major effector cells responsible for eliminating …
Toll-like receptors as a therapeutic target in the era of immunotherapies
Toll-like receptors (TLRs) are the pattern recognition receptors, which are activated by
foreign and host molecules in order to initiate the immune response. They play a crucial role …
foreign and host molecules in order to initiate the immune response. They play a crucial role …
Efficiency of interferon-γ in activating dendritic cells and its potential synergy with toll-like receptor agonists
Interferon-γ (IFN-γ) is a cytokine that plays an important role in immune regulation,
especially in the activation and differentiation of immune cells. Toll-like receptors (TLRs) are …
especially in the activation and differentiation of immune cells. Toll-like receptors (TLRs) are …
[HTML][HTML] Engagement of Toll-like receptor-2 on cytotoxic T-lymphocytes occurs in vivo and augments antitumor activity
N Asprodites, L Zheng, D Geng… - The FASEB …, 2008 - ncbi.nlm.nih.gov
Toll-like receptors (TLRs) are among the fundamental molecules that alert the immune
system to the presence of an infection by recognizing pathogen-associated molecules. Much …
system to the presence of an infection by recognizing pathogen-associated molecules. Much …
Toll-like receptor 7 agonist imiquimod prevents the progression of SLE in MRL/lpr mice via inhibiting the differentiation of T follicular helper cells
X Duan, C Shen, X Zhang, L Wu, J Chen, B Ma… - International …, 2020 - Elsevier
Previous research has recently indicated that TLR7 is able to induce CD4+ T cell anergy,
which is the opposite of the role it plays in innate immune cells. Therefore, TLR7 ligands …
which is the opposite of the role it plays in innate immune cells. Therefore, TLR7 ligands …
Toll-like receptor-induced cytokines as immunotherapeutic targets in cancers and autoimmune diseases
Immune cells of the myeloid and lymphoid lineages express Toll-like receptors (TLRs) to
recognize pathogenic components or cellular debris and activate the immune system …
recognize pathogenic components or cellular debris and activate the immune system …
Toll-like receptor 9 activation of signal transducer and activator of transcription 3 constrains its agonist-based immunotherapy
M Kortylewski, M Kujawski, A Herrmann, C Yang… - Cancer research, 2009 - AACR
Although toll-like receptor (TLR) agonists, such as CpG, are used as immunotherapeutic
agents in clinical trials for cancer and infectious diseases, their effects are limited and the …
agents in clinical trials for cancer and infectious diseases, their effects are limited and the …
Toll-like receptor 2 ligand and interferon-γ suppress anti-tumor T cell responses by enhancing the immunosuppressive activity of monocytic myeloid-derived …
H Shime, A Maruyama, S Yoshida, Y Takeda… - …, 2018 - Taylor & Francis
ABSTRACT CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) suppress
activation/proliferation of cytotoxic T cells, thereby hindering cancer immunotherapy. MDSCs …
activation/proliferation of cytotoxic T cells, thereby hindering cancer immunotherapy. MDSCs …
Triggering of toll-like receptor signaling pathways in T cells contributes to the anti-tumor efficacy of T cell responses
ML Salem - Immunology letters, 2011 - Elsevier
Traditionally, expression of toll-like receptors (TLRs) has been associated with innate
immune cells in particular professional antigen presenting cells and natural killer cells. This …
immune cells in particular professional antigen presenting cells and natural killer cells. This …