UT-7 is a human megakaryoblastic leukemia cell line with absolute dependence on
interleukin-3, granulocyte-macrophage colony-stimulating factor, or erythropoietin (EPO) for …

Thrombopoietin (TPO) is the major regulator of both growth and differentiation of
megakaryocytes. We previously showed that both functions can be generated by TPO in the …

Thrombopoietin (TPO) is implicated as a primary regulator of megakaryopoiesis and
thrombopoiesis. However, the biologic effects of TPO on human acute myeloblastic …

Thrombopoietin (Tpo) is a cytokine that specifically regulates megakaryocyte maturation and
platelet production. Little is known about the molecular and cellular mechanism of the Tpo …

Thrombopoietin (TPO) is a newly identified hematopoietic growth factor that stimulates both
megakaryopoiesis and thrombopoiesis through its interaction with a specific cell surface …

Thrombopoietin (TPO) is a recently identified hematopoietic growth factor that is essential for
the growth and development of megakaryocytes. We have previously shown that TPO …

Thrombopoietin (TPO) is a ligand for c‐mpl that promotes both proliferation and
differentiation of megakaryocytes in vivo and in vitro. We investigated the expression of c …

OBJECTIVE: The development of megakaryocytes is regulated by thrombopoietin (TPO),
which binds to the c-mpl receptor, and by several other cytokines such as interleukin (IL)-6 …

We investigated changes in proliferative potential and surface markers during human
megakaryocytic differentiation, using megakaryocytic cells grown by thrombopoietin (TPO) …

Thrombopoietin (TPO) has been demonstrated to have proliferative effects on hematopoietic
progenitor cells and maturational effects on more committed populations which express a …