Thrombopoietin (TPO) and its receptor (MPL) are important regulators of megakaryopoiesis.
MPL belongs to a cytokine receptor superfamily. To date, all constitutively active MPL …

Thrombopoietin (TPO), the ligand for c-Mpl, is a cytokine that regulates megakaryocyte
growth and development. We have cloned the 5′-flanking region of the human TPO gene …

Thrombopoietin (TPO) plays a critical role not only in proliferation and differentiation of
megakaryocytes but also in erythroid differentiation. We have investigated whether the …

Hematopoietic progenitor cells are the progeny of hematopoietic stem cells that coordinate
the production of precise numbers of mature blood cells of diverse functional lineages …

The in vivo effects of pegylated recombinant human megakaryocyte growth and
development factor (PEG-rHuMGDF), a truncated molecule of recombinant human …

Thrombopoietin (TPO), a lineage-specific cytokine affecting the proliferation and maturation
of megakaryocytes from committed progenitor cells, is believed to be the major physiological …

OBJECTIVE: Thrombopoietin (TPO) and transforming growth factor-β1 (TGF-β1) have been
shown to exert opposite effects on proliferation and megakaryocytic differentiation of …

Thrombopoietin (TPO) is a megakaryocyte growth and differentiation factor. It consists of a
characteristic two domain structure. The amino-terminal domain of TPO has a sequence …

The c-mpl gene encodes a receptor for thrombopoietin (TPO), a cytokine that potently
stimulates megakaryocytopoiesis. To study the mechanisms of c-Mpl activation, we …

Thrombopoietin performs an essential role during hematopoiesis by regulating the
expansion and maturation of megakaryocytes. In keeping with this function …