Potential novel pharmacological therapies for myocardial remodelling

U Landmesser, KC Wollert, H Drexler - Cardiovascular research, 2009 - academic.oup.com
Left ventricular (LV) remodelling remains an important treatment target in patients after
myocardial infarction (MI) and chronic heart failure (CHF). Accumulating evidence has …

Ventricular remodeling in heart failure

MA Gaballa, S Goldman - Journal of cardiac failure, 2002 - Elsevier
This review briefly highlights the major mechanisms of left ventricular (LV) remodeling
following myocardial infarction in heart failure and presents novel strategies to limit infarct …

Ventricular remodeling in heart failure and the effect of β-blockade

JE Udelson - The American journal of cardiology, 2004 - Elsevier
Left ventricular (LV) remodeling has an important role in the progression of cardiovascular
disease. An understanding of the process of LV remodeling has led to greater knowledge of …

Mechanisms of postinfarct left ventricular remodeling

BA French, CM Kramer - Drug Discovery Today: Disease Mechanisms, 2007 - Elsevier
Heart failure secondary to myocardial infarction (MI) remains a major source of morbidity
and mortality. Long-term outcome after MI can be largely be defined in terms of its impact on …

Left ventricular remodelling post-myocardial infarction: pathophysiology, imaging, and novel therapies

S Frantz, MJ Hundertmark… - European heart …, 2022 - academic.oup.com
Most patients survive acute myocardial infarction (MI). Yet this encouraging development
has certain drawbacks: heart failure (HF) prevalence is increasing and patients affected tend …

Pharmacological modulation of cardiovascular remodeling: a guide to heart failure therapy

WJ Remme - Cardiovascular drugs and therapy, 2003 - Springer
Cardiac remodeling is a complex process, which involves genetic, molecular and cellular
changes in cardiomyocytes and the interstitium, leading to progressive structural and …

Relation between left ventricular remodeling and clinical outcomes in heart failure patients with left ventricular systolic dysfunction

JE Udelson, MA Konstam - Journal of cardiac failure, 2002 - Elsevier
Background: A major advance in understanding the pathophysiology of the heart failure
syndrome has been an understanding of the process of left ventricular (LV) remodeling. After …

Drugs for left ventricular remodeling in heart failure

M Frigerio, E Roubina - The American journal of cardiology, 2005 - Elsevier
Left ventricular (LV) remodeling (ie, enlargement and functional deterioration occurring over
time) is among the main mechanisms of progression in heart failure (HF). LV dilatation and …

Cardiac remodeling—concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling

JN Cohn, R Ferrari, N Sharpe… - Journal of the American …, 2000 - jacc.org
Cardiac remodeling is generally accepted as a determinant of the clinical course of heart
failure (HF). Defined as genome expression resulting in molecular, cellular and interstitial …

Left ventricular remodeling after myocardial infarction: from physiopathology to treatment

SA Leancă, D Crișu, AO Petriș, I Afrăsânie, A Genes… - Life, 2022 - mdpi.com
Myocardial infarction (MI) is the leading cause of death and morbidity worldwide, with an
incidence relatively high in developed countries and rapidly growing in developing …