Chemoprevention of colorectal cancer is a promising science that has particular importance
due to the limited success of current treatments for most advanced common malignancies …

Population-based studies have established that long-term intake of non-steroidal anti-
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …

Colorectal cancer is a leading cause of cancer death throughout the world. The high
prevalence and mortality associated with colon cancer make effective prevention and …

The limited success of current treatments for most advanced common malignancies
highlights the importance of cancer prevention. Clinical trials on cyclooxygenase (COX) …

COX-2 is upregulated at an early stage in colorectal carcinogenesis and generates
prostaglandins, which promote cancer cell proliferation, impair apoptosis and enhance …

COX-2 is an isoenzyme of cyclooxygenase that is increased in response to growth factors,
cytokines, and other mitogenic stimuli. Upregulation of COX-2 gene expression and …

Colorectal cancer (CRC) is one of the most common neoplasia in Western countries and the
second leading cause of cancer-related death. The vast majority of cases belong to sporadic …

Cancer is predicted to become the leading cause of death–surpassing heart disease–by the
end of this decade. Colorectal cancer is a major health concern, with more than 1,000,000 …

The decisive epidemiological observation that non-steroidal anti-inflammatory drugs
(NSAIDs) prevent colon and possibly other cancers as well has spurred novel approaches to …

Abstract Cyclooxygenase-2 (COX-2) is an inducible enzyme that regulates prostaglandin
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers …