[HTML][HTML] Kinase inhibitors as potential therapeutic agents in the treatment of COVID-19
Corona virus is quickly spreading around the world. The goal of viral management is to
disrupt the virus's life cycle, minimize lung damage, and alleviate severe symptoms …
disrupt the virus's life cycle, minimize lung damage, and alleviate severe symptoms …
Recent developments in the use of kinase inhibitors for management of viral infections
R Raghuvanshi, SB Bharate - Journal of medicinal chemistry, 2021 - ACS Publications
Kinases are a group of therapeutic targets involved in the progression of numerous
diseases, including cancer, rheumatoid arthritis, Alzheimer's disease, and viral infections …
diseases, including cancer, rheumatoid arthritis, Alzheimer's disease, and viral infections …
Anti‐SARS‐CoV‐2 activity of targeted kinase inhibitors: repurposing clinically available drugs for COVID‐19 therapy
RM Boytz, M Słabicki, S Ramaswamy… - Journal of medical …, 2023 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) remains a major public health concern, and
vaccine unavailability, hesitancy, or failure underscore the need for discovery of efficacious …
vaccine unavailability, hesitancy, or failure underscore the need for discovery of efficacious …
Recent clinical findings on the role of kinase inhibitors in COVID-19 management
Z Malekinejad, A Baghbanzadeh, A Nakhlband… - Life Sciences, 2022 - Elsevier
The highly pathogenic, novel coronavirus disease (COVID-19) outbreak has emerged as a
once-in-a-century pandemic with poor consequences, urgently calling for new therapeutics …
once-in-a-century pandemic with poor consequences, urgently calling for new therapeutics …
[HTML][HTML] Current status of baricitinib as a repurposed therapy for COVID-19
The emergence of the COVID-19 pandemic has mandated the instant (re) search for
potential drug candidates. In response to the unprecedented situation, it was recognized …
potential drug candidates. In response to the unprecedented situation, it was recognized …
[HTML][HTML] Janus kinase inhibitors and coronavirus disease (COVID)-19: rationale, clinical evidence and safety issues
We are witnessing a paradigm shift in drug development and clinical practice to fight the
novel coronavirus disease (COVID-19), and a number of clinical trials have been or are …
novel coronavirus disease (COVID-19), and a number of clinical trials have been or are …
Baricitinib or imatinib in hospitalized COVID‐19 patients: Results from COVINIB, an exploratory randomized clinical trial
A Morales‐Ortega, AI Farfán‐Sedano… - Journal of Medical …, 2023 - Wiley Online Library
Baricitinib and imatinib are considered therapies for coronavirus disease 2019 (COVID‐19),
but their ultimate clinical impact remains to be elucidated, so our objective is to determine …
but their ultimate clinical impact remains to be elucidated, so our objective is to determine …
Efficacy and safety of baricitinib in patients with COVID-19 infection: results from the randomised, double-blind, placebo-controlled, parallel-group COV-BARRIER …
Background The efficacy and safety of baricitinib, an oral selective Janus kinase 1/2
inhibitor, in addition to standard of care (SOC) in hospitalised adults with COVID-19 is …
inhibitor, in addition to standard of care (SOC) in hospitalised adults with COVID-19 is …
[HTML][HTML] Repurposing of kinase inhibitors for treatment of COVID-19
The outbreak of COVID-19, the pandemic disease caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has spurred an intense search for treatments by the …
syndrome coronavirus 2 (SARS-CoV-2), has spurred an intense search for treatments by the …
Janus Kinase inhibitors for the treatment of hospitalized patients with COVID-19
DF Florescu, AC Kalil - Current Opinion in Critical Care, 2021 - journals.lww.com
JAK inhibitors are novel treatment agents in the field of infectious diseases. One JAK
inhibitor, baricitinib has demonstrated significant clinical and survival benefits in hospitalized …
inhibitor, baricitinib has demonstrated significant clinical and survival benefits in hospitalized …