[HTML][HTML] Kinase inhibitors as potential therapeutic agents in the treatment of COVID-19

RR Naik, AK Shakya, SM Aladwan… - Frontiers in …, 2022 - frontiersin.org
Corona virus is quickly spreading around the world. The goal of viral management is to
disrupt the virus's life cycle, minimize lung damage, and alleviate severe symptoms …

Recent developments in the use of kinase inhibitors for management of viral infections

R Raghuvanshi, SB Bharate - Journal of medicinal chemistry, 2021 - ACS Publications
Kinases are a group of therapeutic targets involved in the progression of numerous
diseases, including cancer, rheumatoid arthritis, Alzheimer's disease, and viral infections …

Anti‐SARS‐CoV‐2 activity of targeted kinase inhibitors: repurposing clinically available drugs for COVID‐19 therapy

RM Boytz, M Słabicki, S Ramaswamy… - Journal of medical …, 2023 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) remains a major public health concern, and
vaccine unavailability, hesitancy, or failure underscore the need for discovery of efficacious …

Recent clinical findings on the role of kinase inhibitors in COVID-19 management

Z Malekinejad, A Baghbanzadeh, A Nakhlband… - Life Sciences, 2022 - Elsevier
The highly pathogenic, novel coronavirus disease (COVID-19) outbreak has emerged as a
once-in-a-century pandemic with poor consequences, urgently calling for new therapeutics …

[HTML][HTML] Current status of baricitinib as a repurposed therapy for COVID-19

M Saber-Ayad, S Hammoudeh, E Abu-Gharbieh… - Pharmaceuticals, 2021 - mdpi.com
The emergence of the COVID-19 pandemic has mandated the instant (re) search for
potential drug candidates. In response to the unprecedented situation, it was recognized …

[HTML][HTML] Janus kinase inhibitors and coronavirus disease (COVID)-19: rationale, clinical evidence and safety issues

M Gatti, E Turrini, E Raschi, P Sestili, C Fimognari - Pharmaceuticals, 2021 - mdpi.com
We are witnessing a paradigm shift in drug development and clinical practice to fight the
novel coronavirus disease (COVID-19), and a number of clinical trials have been or are …

Baricitinib or imatinib in hospitalized COVID‐19 patients: Results from COVINIB, an exploratory randomized clinical trial

A Morales‐Ortega, AI Farfán‐Sedano… - Journal of Medical …, 2023 - Wiley Online Library
Baricitinib and imatinib are considered therapies for coronavirus disease 2019 (COVID‐19),
but their ultimate clinical impact remains to be elucidated, so our objective is to determine …

Efficacy and safety of baricitinib in patients with COVID-19 infection: results from the randomised, double-blind, placebo-controlled, parallel-group COV-BARRIER …

VC Marconi, AV Ramanan, S de Bono, CE Kartman… - MedRxiv, 2021 - medrxiv.org
Background The efficacy and safety of baricitinib, an oral selective Janus kinase 1/2
inhibitor, in addition to standard of care (SOC) in hospitalised adults with COVID-19 is …

[HTML][HTML] Repurposing of kinase inhibitors for treatment of COVID-19

E Weisberg, A Parent, PL Yang, M Sattler, Q Liu… - Pharmaceutical …, 2020 - Springer
The outbreak of COVID-19, the pandemic disease caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has spurred an intense search for treatments by the …

Janus Kinase inhibitors for the treatment of hospitalized patients with COVID-19

DF Florescu, AC Kalil - Current Opinion in Critical Care, 2021 - journals.lww.com
JAK inhibitors are novel treatment agents in the field of infectious diseases. One JAK
inhibitor, baricitinib has demonstrated significant clinical and survival benefits in hospitalized …