Shiga toxins (Stx) are cytotoxins involved in severe human intestinal disease. These toxins
are commonly found in Shigella dysenteriae serotype 1 and Shiga-toxin–producing …

The structural genes for Shiga toxin, designated stx A and stx B, were cloned from Shigella
dysenteriae type 1 3818T, and a nucleotide sequence analysis was performed. Both stx A …

Toxin–antitoxin systems are widespread in bacterial genomes. They are usually composed
of two elements: a toxin that inhibits an essential cellular process and an antitoxin that …

Detection of Shiga toxin-producing Escherichia coli (STEC) by culture methods is advisable
to identify the pathogen, but recovery of the strain responsible for the disease is not always …

The A-subunit polypeptides of Shiga toxin, the Shiga-like toxins (SLTs), and the plant lectin
ricin inactivate eucaryotic ribosomes by enzymatically depurinating 28S rRNA. Comparison …

Background Shiga toxin 2 (Stx2) is a major virulence factor in gastrointestinal diseases
caused by Escherichia coli. Although Stx2a (prototypical Stx2) is well-studied, all seven …

Shiga toxin-producing Escherichia coli (STEC), especially of serotype O157: H7, cause a
zoonotic food or waterborne enteric illness that is often associated with large epidemic …

Many human diseases are caused by pathogens that produce exotoxins. The genes that
encode these exotoxins are frequently encoded by mobile DNA elements such as plasmids …

Escherichia coli strain O157: H7 is a major cause of food poisoning that can result in severe
diarrhea and, in some cases, renal failure. The pathogenesis of E. coli O157: H7 is in large …

Shiga-like toxin (SLT-II) was purified to apparent homogeneity from Escherichia coli K-12
strain NM522 containing the cloned toxin genes on recombinant plasmid pEB1. Purification …